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and alcoholic extract of the tissues shaken with freshly precipi-
tated washed mercurous chloride gives a black compound, which
is soluble in nitric acid.

POTASSIUM CHLORATE

I. Extract the tissues with water and filter, add excess of silver
nitrate and filter if there is a precipitate; add a little sul-
phurous acid and heat. If chlorate is present this decomposes
it with the formation of a chloride, which gives a precipitate with
the excess of AgNOj in the solution:

AgClOa + 3H2SO8 = AgCl + 3H2SO4
Add dilute HNO3 — silver sulphite dissolves, if present, silver chlo-
ride is insoluble.

II. Chlorates liberate chlorine from hydrochloric acid and the
gas will liberate iodine from potassium iodide.

(a) Heat a solution containing a chlorate with concentrated
HCl — free chlorine is given off. Pass the gas into a solution of
potassium iodide; free iodine is liberated and can be separated
by dissolving in chloroform.

Chromic acid and bichromates also liberate chlorine from
hydrochloric acid.

ACTIVE SUBSTANCES WHICH MAY CAUSE POISONING, BUT

WHICH ARE HARD TO DETECT, AND WHICH FIND NO

PLACE IN THE STAS-OTTO METHOD

Cantharidin is the vesicating principle of Spanish fly.
Chemically it is the anhydride of cantharidic acid.



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CHEMICAL PHARMACOLOGY



H


H




C CH, - COOH


C CHj-


-COOH


/


\x


/ \/




hC


C— OiH =


H2C


C—


+ H,0


CH,


1 CH.I 1




UC \C— CO OH


HjC \C-CO




\ /


\ /




C


c




Ha


Hi




Cantharidic acid


Cantharidin





It occurs as small, colorless glistening crystals which melt at
214°-218°C. and sublimes at higher temperatures in white
needles. The pharmacopeia gives a method for the extraction
of the active substance from Spanish fly. There is no chemical
test for it. The physiological test consists in dissolving a little
of the substance in a fatty oil and rubbing it on a spot oh the arm
or chest. A blister will be formed in a short time if cantharidin
be present.

SANTONIN, SULPHONAL, TRIONAL

These substances are not extracted under the conditions of the
Stas-Otto process. They are not soluble in acid ether solution.
Extract the tartaric acid solution of the organs with hot alcohol,
filter. If a colored solution results add a little animal charcoal
and heat again. Filter while hot, cool and extract the acid
solution several times with chloroform. Evaporate the chloro-
form which may contain sulphonal, trional, santonin.

1. Santonin, see page 220.

2. Sulphonal, see also page 46.

3. Trional, see page 46.

Cytisine is an alkaloid of unknown structure, CiiHi40N2,
found to the extent of 1.5 per cent, in the ripe seeds of Golden
Chain — Cytisus Laburnum. Cytisine forms large colorless
rhombic crystals which melt at 153°. It causes convulsions
similar to strychnine, but it is also irritating to the gastro-intesti-
nal tract, and for this reason may cause vomiting, and it also
stimulates the vomiting center directly. Cytisine also resembles
nicotine in action. In the tartaric extract in the Stas-Otto



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TOXICOLOGY 405

method, it can be extracted with chloroform in alkaline solu-
tion of NaOH.

Test I. — Ferric chlorid colors cytif^ine and salts blood red. The
color is discharged by hydrogen peroxid which changes to blue when •
heated on water bath.

Test n. — Nitrobenzene containing dinitro-thiophene pro-
duces a reddish violet coloration.

Digitalis. — Nothing is known regarding the fate of digitalis in
the body, consequently extracts of the tissues cannot be tested
chemically for it. It has been claimed that more of it acciunu-
lates in the heart than in other tissues. This has been shown by
physiological tests; no test for the drug as a whole is at hand.

Digitonin when dissolved in sulphuric acid, gives a red color
with bromine water.

Digitoxia. — I. This dissolves in concentrated HCl, with a
brownish green coloration, which is imchanged by the addition
of bromine.

II. Kiliani's test. Digitoxin dissolved in a little glacial acetic
acid containing a trace of ferric sulphate. When superimposed
on strong sulphuric acid containing a trace of ferric sulphate
gives a dark ring. On standing the acetic acid layer becomes a
deep indigo blue.

Digitalin. — This dissolves in concentrated sulphuric acid with
an orange yellow color, which changes to red on addition of
bromine water, or ferric chloride, or after an hour with the
addition of these oxidizing agents.

ERGOT

Ergot contains a red pigment — sclererythrin — which ^is charac-
teristic of ergot. This cannot be found in tissues poisoned with
ergot, but the material containing ergot, Uke flour, bread, etc.
will give the following test.

Test I. — If flour containing ergot be treated with a very
dilute solution of anilin violet, the stain is absorbed by the
damaged particles of the grain, while the normal particles are
not stained.

Test II. — Extract the flour with 10 to 15 times its volume
of 40 per cent, alcohol heated to 40°. Filter and add basic lead
acetate to the filtrate. Filter. Press the precipitate between



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406 CHEMICAL PHARMACOLOGY

filter papers warm and add a few drops of saturated borax solu-
tion. If ergot be present a red violet color appears.

REAGENTS AND SOLUTIONS

Ammonium Molybdate Solution for Phosphates. — Dissolve
50 gm. of molybdic acid in 72 cc. cone, ammonia and 136 water;
slowly and with constant stirring pour the solution into 245 cc.
of nitric acid, cone, and 574 cc. of water. Keep this mixture in
a warm place for several days. Decant and preserve in glass
stoppered bottles.

Barf oed's Reagent is prepared by dissolving 45 grams of neutral
cupric acetate crystals in 900 cc. of water and filtering. Add
6 cc. of 10 per cent, acetic acid to the filtrate and dilute to a
liter. A portion of the reagent when heated on the water bath
should show no reduction.

Benedict's Qualitative Reagent for Glucose.

•Copper sulphate 17.3 gm.

Sodium citrate 173.0 gm.

Sodium carbonate, anhydrous 1000.0 gm.

Dissolve the copper sulphate separately in about 150 cc. of
water and add slowly to the filtered solution of the other two in
about 800 cc, and make up to 1000 cc.

Esbach's Reagent. — Dissolve 10 grams of picric acid and 20
grams of citric acid 'in 1 Uter of water,

Fehling's Solution

A. Copper sulphate 69.28 gms.

Water 1000.00 cc.

B. Potassium and sodium tartrate 346.0 gms.

Potassium hydroxide 100. 00 gms.

Water to 1000.00 cc.

Mix equal volumes of A and By and then add four volumes
water just before using. This mixed solution does not keep well.

Froehde's Reagent is a solution of molybdic acid in sulphuric
acid prepared by dissolving 0.5 gram of molybdic acid in 100 cc.
of hot, pure concentrated sulphuric acid. The solution should be
colorless and it does not keep long.

Gold chloride is used in a 3 per cent, aqueous solution.



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TOXICOLOGY 407

Iodine Solutioiii aqueous (LugoPs). — Dissolve five grams of
iodine and ten grams of potassium iodide in about 20 ce. of water.
When completely dissolved add a sufficient quantity of distilled
to make the product weight 100 grams.

Iodine solution; alcoholic, about 1 gram of iodine in 100 cc. of
alcohol (96 per cent.).

Mayer's Reagent (merciuic potassimn iodide solution) is
prepared by dissolving 1.36 grams of corrosive mercuric chloride
in 60 cc. of distilled water, and 5 grams of potassimn iodide in
10 cc. of water. Mix the two solutions and then add sufficient
water to measure 100 cc.

Millon's Reagent. — Dissolve 100 grams of mercury in 200
grams of strong nitric acid, by the aid of heat finally, and after
cooling dilute the solution with twice its volume of water.

Nessler's Reagent. — Place 35 grams of potassium iodide and
50 grams of mercuric iodide, both finely powdered, in a 500 cc.
volmnetric flask and add about 200 cc. of water: Now add to this
mixture in the flask; with constant shaking, 250 cc. of a cooled
20 per cent, solution of sodium hydroxide. Then make up to
500 cc. Set aside in a warm place for several days and decant
the clear Uquid for use.

Phospho-tungstic acid solution is prepared by adding a Uttle
20 per cent, phosphoric acid to an aqueous solution of sodium
tungstate.

Platinum chioride is used in a 5 per cent, solution.

Sodium Hypochlorite Solution. — Prepare a solution of calcimn
hypochlorite from bleaching lime and then precipitate the
calciimi by adding an excess of sodium carbonate — allow to
settle and use the clear supernatant Uquid.

Magnesia Mixture. — Dissolve 52.5 grams of crystalUzed
magnesium sulphate and 105 grams of ammonium chloride in
about 300 cc. of water and add 180 cc. of concentrated ammon-
ium hydroxide. Dilute to 600 cc. Filter off turbidity which
may develop on standing.



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INDEX



Abrin, 323, 381
Acetal, 58, 184
Acetaldehyde, 55
Acetanilide, 112, 120, 380, 392
Acetic acid, 66

Acetoacetic acid, formation by ami-
no acids, 319-320
Aceto-catechol, activity of deriva-
tives of, 232-233
Acetone, 62-63, 380, 387
Acetphenetidin, 111, 120
Acetyl atoxyl, 365
Acetyl number, 155
Acid number of fats, 151
Acid taste, 208
Acidosis, 357-359

detection of in body, 359
Acids, pharmacology of, 78
Aconitine, 296
Acridine, 132, 363
Acrolein, 30
Adenase, 287
Adenine, 283-287
Adrenaline, 245
Adrenalone, 236
Adsorption, 349
Aetioporph3rrin, 331
Agar, 140

Agglutinins, vegetable, 322
Agmatine, 238
Alanine, 304, 312
Albuminoids, 300
Albumins, 299
Alcohol, absolute, 19

action of, 20

amyl, 26

as a food, 21

butyl, 24-25

cetyl, 30



Alcohol, dihydric, 28
fate of in body, 22
myricyl, 30
pharmacology of in relation to

chemistry, 31
propyl, 24r-25
toxicity of various, 25
trihydric, 29
Alcohols, 17

Aldehydes, 48-49
Alkalies, 381, 403
Alkalinity, actual and potential, 355

of blood, 356
Alkaloidal factors, 297
Alkaloids, 223-298
chemistry of, 225
general characteristics of, 224
isolation of, 292
utilization by plant life, 298
Alkanet, 334
Alkaptonuria, 320-321
Alkyl groups, physiological action

of, 230
Alkyl radicals, depressive action of, 32
Alizarine-Bordeaux, 132
Allantoine, 290-291
Alloxan, 288
Alloxantine, 288
Aloes, 195
Amber, 181
Amines, 225-228
Amines, physiological action of, 230-

231
Amino acids, metabolism of, 315
occurrence in plants, 302
occurrence in the urine, 317
optical properties, 314
pathology of, 319-322
properties of, 308-309
Ammoniac, 182
Ammonium molybdate solution, 406



409



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410



INDEX



Amygdalin, 193-198

Analgesics, 41

Anesthesia, stages of ether, 33-34

theories of, 36
Anesthesine, 267
Anesthetics, 32
Aniline, 110, 230, 380-387
Aniline tests, 112
Animal glucosides, 201
Anisol, 90
Annato, 334

Anthracene derivatives, 195
Anthracenes, 129
Anthragallol, 132
Anthranilic acid, taste of, 210
Anthranol, 222
Anthrapurpurin, 132
Anthraquinone, 129
Antimony, 381, 395-397, 401
Antipyrine, 113, 117, 119, 380-381,

392
Apocodeine, 279
Apomorphine, 276, 279
Arbutin, 192
Arecoline, 257-258
Arginine, 234, 238, 303, 308
Aristol, 366
Aromatic alcohols, 101
Arrenhal, 366
Arsacetin, 365
Arsenic, 381, 395-398, 401

compounds, 364

fate in body, 367-368
Arsphenamine, 366
AsafcBtida, 176, 182
Ash, 10-11

Aspartic acid, 306, 315
Aspidium, 181
Aspidosamine, 296
Aspidospermatine, 296
Aspirin, 106
Astringents, 214, 369
Atophan, 109
Atoxyl, 364
Atropine, 239, 244, 251, 271-272,

368, 380
Attar of Roses, 169



B



Balsams, 180-182

Barbituric acid, 285-286

Barfoed's reagent^ 406

Barium, 381, 394, 399-401

Bear fat, 145

Beer, 20

Bee's wax, 164

Benedict's sugar reagent, 406

Benzaldehyde, 100, 103, 193, 380,
387

Benzene, 13, 87-89

Benzine, 13, 14

Benzoic acid, 104, 105

Benzyl alcohol, 101-102

Benzyl amine, 230

Berberine, 262

Betaine, 234

Bikhaconitine, 296

Bile pigments, 333

Bismuth, 381, 395, 398-401

Bitter principles, 204

Bitter taste, 208-214

Bitters, pharmacologic classifica-
tion of, 205

Black pepper, 181

Blood pressure, effect of amines on,
231

Boiling point, changes with mole-
cular weight, 15

Bomeol-camphor, 177

Brandy, 20

Bromine compoimds, 87

Bromine test for fats, 158

Bromopin, 86

Brucine, 251, 257, 380

Brucine, ethyl, 228

Buffer value, 355



Cacodyl oxide, 365
Cacodylic acid, 365
Cadaverine, 231, 234, 240-241
Cadmium, 381, 395, 398, 401
Caffeine, 287, 380-381, 392



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INDEX



411



Cafifeine, action of, 288

assay of, 292

economic use of, 291

diuretic action of, 289

fate of, 290

group, 283

isolation of, 293
Camphor, 178-179
Camphor monobromata, 178
Camphorol, 179
Cantharidin, 381, 392, 403-404
Caoutchouc, 182
Capsicum, 182
Caramel, 334
Carbamate, 313

Carbamino, reaction of aniino acids,
Carbon disulphide, 380, 388
Carbohydrate tests, 137
Carbohydrates, 135
Carbolic acid, distribution of in

body, 92
Carbonic acid, 67-68
Carminatives, 177
Carmine, 334

Camivora, poisoning of, 374
Carvacrol, 181
Castor oil, 149
Castor oil group, 146
Catechol, 93-94, 233, 235
Celluloses, 136, 140
Central nervous system, toxic ac-
tion of heavy metals on,
371
Cerebron, 199
Cerebronic acid, 199
Chaulmoogra oil, 148
Chloral, 57-61
Chloral, fate of in body, 59

in urine, 61
Chloral hydrate, 380, 389
Chloraldehyde, 57-58
Chlorates, 381, 403
Chloretone, 63-64
Chlorocodeine, 280
Chloroform, 34-35, 41-42, 380
Chlorophyll, 269, 328-335

fate in the body, 333



Chlorophylls and hemoglobins, re-
lationship of, 329

Cholesterol, 153, 166-169

Choline, 234, 240, 242

Chromium, 381, 399-401

Chromoporteins, 300

Chrysophanic acid, 131, 196, 222

Chrysorobin, 219, 222

Cinchona bark, 260

Citric acid, 73-^4

Cloves, 177

Clupanodonic acid series, 148

Coca, 265, 267

Cocaine, 251, 265-267, 380

Cocoanut oil, 147

Codeine, 239, 276, 278-279, 281, 380

Coffee, caffein in, 286

Colchiceine, 29^296

Colchicine, 29^296, 380, 392

Collidine, 250

Colloidal copper, gold, platinum and
silver, 372

Colloidal metals, 372

Colloids, 33^350

Colloids, changes in during precipi-
tation, 342

Colloids, electrical condition of, 341

Colloids, protective power of, 342

Colormetric method, 351

Coniferin, 200

Coniferyl alcohol, 200

Coniine, 239, 250-252 .

Convallamarin, 197

Copaiba, 182-183

Copper, 177, 395, 397-399, 401

Coriander, 177

Corrosive salts, 369

Cottonseed oil, 149, 177

Cranberries, 183

Creatine, 249

Creatinine, 249

Creosote, 98, 380, 390

Cresols, 96-97

Crocus, 334

Croton, 322, 381

Croton oil, 149

Crude fiber, 140



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412



INDEX



Cubebs; 177, 182
Cudbear, 334
Curara, 228, 230
Curcin, 322, 381
Curcumin, 334
Cyanogenetic glucosides, 198
Cysteic acid, 320
Cysteine, 306, 320
Cystine, 306
Cystinuria, 241
Cytisine, 271, 381, 404

D



Ergot, derivatives of, 245
Ergot alkaloids, 234
Ergotinine, 296
Ergotoxine, 234, 245, 296
Esbach's reagent, 406
Eserine, 294
Ethane, 16
Ether, 34, 36-39
Ethyl alcohol, 19, 380, 389

tests for, 23-24
Ethyl chloride, 41
Eugenol, 200
Europhen, 82



Dhurrin, 198

Diastases, 324

Diffusion, 375

Digallic acid, 214

Digitalein, 198

Digitalin, 197

Digitalis, 197, 381, 392, 405

Digitoxin, 197

Disaccharides, 135

Dithymol-di-iodide, 81-82

Diuresis, 289

Drug, definition of, 1

Drugs, classification of, 2-4

Dulcin, taste of, 210 ^

Ecgonine, 266
Elaidic acid, 148
Elaidin test for fats, 157
Elatenn, 219, 222
Electro-potential method, 351
Emodin, 131, 133, 196
Emulsoid, 338-339
Enolforms, 116
Enzymes, 323-328

fate in body, 325
Epinephrine, 231, 234-237

stimulation of sympathetics by,
235-236

tests, 237
Ergot, 231, 244-245, 320, 381, 405



Fat, appearance after anesthesia,
159

butter, 147

formation from protein, 163

formation of from carbohy-
drate, 162

from carbohydrate, 161-162

from fat, 161-162

human, 147

in urine, 164

influence of diet on, 146

wool, 165
Fats, constants of, 152

fate of, 160

fate of in the body, 164 •

hydrogenated, 155

melting point of, 152

properties of, 149-150

rancidity of, 159

significance (^, 160
Fatty acids, fats and oils, 144
Fehling's solution, 138, 406
Fermentation, 139
Ferments, table of, 326-328
Fixed and volatile oils, differences

between, 174
Flavopurpurin, 133
Flavoring agents, 177
Food, definition of, 1
Formaldehyde, 50-54
Formic acid, 65



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INDEX



413



Fowler's solution, 364
Frangula, 196
Froekde's reagent, 406
Furfural, 137
Fusel oil, 27

G

Galactose, 138

Galactosides, 184

Gallic acid, 95, 216

Gallotanic acid, 214

Gamboge, 182-183

Gas chain method, 351-352

Gas pressure, relation to osmotic

pressure, 375-377
Genito-urinary disinfectants, 177
Gel formation, 339
Gin, 20
Ginger, 182
Gliadins, 300
Globulins, 299
Glucose formation by amino acids,

319-320
Glucophore group, definition of, 211

list of, 211-214
Glucoproteins, 300
Glucosides, 184-204

action of, 202

animal, 199

composition of, 189

cyanogenetic, 198

fate of, 202

functions of, 202

table of, 191

tests for, 203-204
Glutamic acid, 306, 316
Glutelins, 299
Glyceric acid, 316
Glycerine, 29, 312
GlycocoU, 304
Glycol, 28^29
Glycolaldehyde, 29
Glycuronic acid, 176
Glycyrrhizin, 198
Glyoxal, 29



Glyoxaline, 273
Goa powder, 222
Gold chloride, 406
Gout, 290

Guaiacum-wood, 182
Guanidine derivatives, 238
Guanine, 283-287
Gum resins, 181-183
Gums, 136, 142
Gynocardin, 198

H

Hsematin, 332

Hsematinic acid, 329

Hsemoporphyrin, 331

Heart, effect of alcohols on, 25

Heavy metals, 368-372

Helleborin, 198

Hematic acid, 333

Hematoporphyrin, 331

Hemicellulose, 141

Hemoglobins, 300, 333

Hemotoxylin, 334

Herbivora, poisoning of, 374

Hetero-cyclic compounds, 134

Hexamethylenamine, 54

Hexone bases, 238

Hippuric acid, 106

Histamine, 234, 246, 322

Histidine, 238, 245-246, 308, 322

Histones, 300

Homogentisic acid, 317-318, 321

Hordenine, 237

Hyderabad Commission, 37

Hydrargyri iodidi, 364

Hydrastine, 262-264, 380

Hydrastinine, 262-264

Hydro-cotamine, 265

Hydrocyanic acid, 75-77, 380

Hydrogen, 7-8

Hydrogen ion concentration, 352-

354
Hydroquinone, 93
Hygrine, 267
Hyoscine, 272
Hyoscyamine, 239



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INDEX



Hypnotics, 41, 43, 45
•Hypoquebrachine, 296
Hypoxanthine, 291



Indaconitine, 296
Indican, 200, 334
Indigo Blue, 201

white, 201
Inks, 215
Inorganic acids, pharmacology of,

373-4
Indoxyl, 201, 335
Iodine number of fats, 154-155

solution, 407
lodoalbin, 84

Iodoform, 80-81, 85-86, 380, 390
lodol, 82
Indole, 202, 335
lodopin, 83
lodoHspongin, 84

Irritant action of heavy metals, 371
Isoamylamine, 234
Isomerism, 24
Isopurpuric acid, 78



Jalap, 182
Jalapin, 193
Japaconitine, 296



Kerosene, 14
Ketones, 62
Kidney function, 127
Kola nuts, caffeine in, 286
Kuskhygrine, 267
Kynurenic acid, 321



Lactams, 310

Lactic acid, 74-75, 315



Lactims, 310
Lanolin, 165, 178
Laudanine, 279
Lavender, 177, 334
Lead, 381, 395, 398-401
Lecithin, 243
Lecithoproteins, 301
Lemon, 177
Leucine, 26, 302, 305
Lignoceric acid, 199
Ligroin, 14

Linolic acid series, 148
Linseed oil group, 146
Lipoproteins, 301
Losophan, 83
Lotusin, 198
Lupine, 271
Lupulin, 182
Luqor arseni, 364
Lyotrope, 340-341
Lysine, 238, 308

M

Magnesia mixture, 407

Malodorous oils, 177

Malonic acid, 70

Mandelic acid, 194, 271

Maumen^ or sulphuric acid test, 158

Mayer's reagent, 407

Menthol, 179-180

Mercaptans, 30

Mercury, 381, 398, 401

Mesotan, 108

Meta-proteins, 301

Methane, 1^16

Methyl alcohol, 18, 380, 390

Methylated compounds, 249

Methylation in animal body, 249,
270

Meyer-Overton, Theory of anes-
thesia, 36

Millon's reagent, 407

Mineral acids, 381, 401

Monosaccharides, 135

Moore and Roaf, Theory of anes-
thesia, 37



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INDEX



415



Morphine, 239, 251, 276, 281, 381

methyl, 228
• pharmacology of, 279
Mucic acid, 137
Murexide, ,79

test, 288
Muscarine, 234, 240

pharmacological action of, 244
Mustard oil, 192
Myronic acid, 192
Myrrh, 183

N

Naphthalenes, 120
Naphthols, 129
Narceine, 381

Narcotine, 251, 264, 279, 380
Neo-salvarsan, 367
Nessler's reagent, 407
Neurine, 240, 242
Neutral principles, 219
Nicotine, 239, 247, 251-254, 380
Nicotine, ethyl, 228
Nicotinic acid, 255-256
Niger, 271
Nitric acid, 401-402
Nitrobenzene, 380, 390
Nitrogen, 7-9
.Nitrogen bases, 223-298
Nitrophenols, 112
Nosophen, 83, 126
Novacaine, 267
Nucleic acid, 290
Nucleo proteins, 300

O

Odors, chemistry of, 207-208

classification of, 205-207

physics of, 207-208
Oils, classification of, 145-146

dr3mig, 145

non-drying, 145

essential, 169

ethereal, 169

solubility, in alcohol of, 149



Oils, malodorous, 177

Oleic acid series, 147

Oleoresins, 181-182

Olive oil, 149

Olive oil group, 145

Opianic acid, 262-263

(^ium, 381

Opsonic index, 344

Optical activity, 71-72

Oxalic acid, 69

Organic acids, 64

Ornithine, 238, 241

Osmophore groups, 207

Osmosis, 375

Osmotic pressure, relation to
boiling point, 377-8

Osmotic pressure, relation to freez-
ing point, 377-378

Oxalates, 402

Oxalic acid, 381

Oxygen, 10



Palm oil, 148
Pancreatic ferments, 324
Papaverine, 261, 282
Paraffins, 12
Paraldehyde, 57

Paralytic action of alkaloids, 228
Pectin, preparation, 144
Pectins, 143
Pelletierine, 270
• Pentosides, 184
Peppermint, 177
Peptides, 301
Peptones, 301
Peru, balsam of, 183
Petrolatum, liquid, 14
Petroleum, 13
Petroleum ether, 14
Pharmacology, definition of, 1
Phenacein, 112, 121, 380, 392
Phenanthrene, 275
Phenetidin, 111-112
Phenol, properties of, 91-92
Phenols, 90, 380, 390



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INDEX



Phenols, reactions of, 99-102
Phenolphthalein, 124
Phenolsulphonephthalein, 127
Phenyl-alanine, 303-307, 321
Phloretin, 195
Phloridzin, 189, 194
Phloroglucinol, 95

taste of, 210
Phosphine, 363-364
Phosphoproteins, 300
Phosphorus, 361-363

isolation of, 380-387
Phosphotungstic acid solution, 407
Phrenosin, 199
Phthalic acid, 125
Phthalimide, 210
Physostigmine, 294-295, 380
Phytosterol, 153
Phytotoxins, 322-323
Picolinic acid, 255
Picramic acid, 78, 99
Picric acid, 98-99, 380, 392
Picrotoxin, 219-222, 380, 392
Pilocarpine, 244, 274-275, 380-381
Pilocarpine, action of, 274
Piperazine, 310
Piperic acid, 248
Piperidine, 135, 226, 242, 247-248,

260, 268
Pituitarine, 246
Plant bases, 223-298
Platinum chloride, 407
Podophyllum, 182
Poison, definition of, 1
Poisons, isolation of, 379-389
Poisonous proteins, 322
Polysaccharides, 135
Potassium cyanide, 387
Precipitation of colloids, 369-371
Pressor substances, 231
Prolamines, 300
Proline, 303, 307-308
Protamines, 300
Proteans, 301
Proteins, 298-304

coagulated, 301

color reactions of, 303



Proteins, comparison of animal and
vegetable, 302

composition of, 303

conjugated, 300

derived, 301

English classification, 302

hydrolytic products of, 304

precipitation reactions of, 304
Proteoses, 301
Proximate principles, 2
Prulaurasin, 198
Ptomaines, 239, 381 '
Purin metabolism, 290
Purine, 283-287
Purpuric acid, 288
Purpuroxanthin, 133
Putrescine, 234, 240
Pyramidon, 118-119, 380
Pyrazolon, 115
I^ridine, 134

alkaloids, 247-249, 251
Pyrocatechol, 94
Pyrocatechol, t^st*^ of, 210
Pyrogallic acid, 9o
Pyrogallol, 95, 216

taste of, 210
Pyrrol, 250, 269, 330
Pyrrolidine alkaloids, 267
IVrollidine, 268-269
Pyruvic acid, 312



Quaternary ammonium bases, 22^

231
Quebrachamine, 296
Quebrachine, 296
Quebractio alkaloids, 296
Quinine, 251, 259-261, 380
Quinol, 93
Quinoline, 258

alkaloids, 259
Quinones, 93, 131

R

Rattlesnake fat, 146

Reaction of living matter, 350-361



Digiti



zed by Google



INDEX



417



Reichert Meissel number, 156
Regulating mechanism of blood

reaction, 354
Resins, 181-182
Resorc^nol, 42, 92-93

taste of, 210
Rhubarb, 196
Ricin, 322, 381
Ricinoleic-oleic series, 148
Robin, 322, 381
Rose, 177
Rosolic acid, 42
Rum, 20



S



Sabromine, 86
Saccharin, 122

taste of, 210

taste of derivatives of, 210
Salicylic acid, 106, 380, 392

tests, 121
Saligenin, 103, 194
Saline taste, 208
Salol, 101, 107
Salol principle, 101
Salt action, 374

phannacology of, 379
Salts in body, 378
Salvarsan or "606," 366-367
Sambunigrin, 198
Sandalwood, 177
Santonic acid, 219
Santonin, 219-220, 381, 404
Saponification, 177



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