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Annual report : National Institute of Environmental Health Sciences (Volume 1982) online

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and malic dehydrogenase, respectively.

Further biochemical analyses of T-cells, B-cells, and macrophages in aging rats
will be performed as well as immune functional assays to determine the nature
of the relationship between these variables.

SIGNIFICANCE TO BIOMEDICAL RESEARCH AND THE PROGRAM OF THE INSTITUTE : Information
on biochemical alterations of lymphoid organs during aging may be useful for
therapeutic intervention and will improve our understanding of the decline in
host resistance that occurs during aging.



600



SMITHSONIAN SCIENCE INFORMATION EXCHANGE
PROJECT NUMBER (Oo NOT use this space)



U.S. DEPARTMENT OF

HEALTH AND HUMAN SERVICES

PUBLIC HEALTH SERVICE

NOTICE OF

INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER

ZOl ES 21022-01 CTEB



PERIOD COVERED , „„ ,„„„

October 1, 1981 to September 30, 1982



TITLE OF PROJECT (80 characters or less)

Effects of Immunotoxic Chemicals on Intermediary Metabolism of Mouse Lymphoid
Tissues



NAMES, LABORATORY AND INSTITUTE AFFILIATIONS, AND TITLES OF PRINCIPAL INVESTIGATORS AND ALL OTHER
PROFESSIONAL PERSONNEL ENGAGED ON THE PROJECT



PI: Michael P. Dieter
Other: Ralph Wilson



Physiologist
Technician



CTEB
CPB



NIEHS
NIEHS



COOPERATING UNITS (if any)

Systemic Toxicology Branch, National Toxicology Program, NIEHS



lab/branch

Carcinogenesis and Toxicology Evaluation Branch



INSTITUTE AND LOCATION . . ,,,..,_., ^ n . n-i-inn

NIEHS, NIH, Research Triangle Park, North Carolina 27709



TOTAL MANYEARS:



1.5



PROFESSIONAL:



0.5



OTHE)^:



1.0



CHECK APPROPRIATE 80X(ES)
□ (a) HUMAN SUBJECTS

D (al) MINORS D (a2) INTERVIEWS



n (b) HUMAN TISSUES



^ (c) NEITHER



SUMMARY OF WORK (200 words or less - underline keywords)

The correlation between chemically-induced immune defects and biochemical defects
in lymphoid tissues (thymus, spleen, bone marrow) and specific-populations of
lymphoid cells (pleuripotent stem cells, granulocyte-macrophage precursors,
T-cells, B-cells, peritoneal and pulmonary, macrophages) were investigated in in
vitro and in vivo studies. Rate limiting enzymes in the hexose monophosphate
shunt, glycolysis and the tricarboxylic acid cycle, and marker enzymes in
macrophages, have been assayed. Change in substrate flow through these bio-
synthetic pathways were caused by immunotoxic chemicals (mercuric chloride,
methyl and ethyl carbamate, DES, asbestos) and tissue-specific pathway inhibition
was correlated with functional defects in the immune system.



601



PHS-6040
(Rev. 2-81)



PROJECT DESCRIPTION ZOl ES 21022 -01 CTEB

M ETHODS EMPLOYED : Current biochemical methods utilizing conventional UV and
centrifugal analysis spectrometry, and radioenzymatic assays are utilized.

MAJOR FINDINGS AND PROPOSED COURSE : Assay of six rate limiting enzymes for
glucose metabolism via monophosphate shunt, glycolysis, or tricarboxylic acid
cycle were standardized in bone marrow, macrophages, thymus, and spleen.

Lymphoid tissues from mice treated with various classes of chemicals revealed
patterns of response consistent with specific T-cell immunotoxicity. Mercuric
chloride, methyl, and ethyl carbamate, diethlystilbestrol , alpha-dinestrol , and
17 e-estradiol caused defects in T-cell immunity and specific inhibition of
enzymes from the glycolytic pathway in thymus,. Lymph nodes are serving as model
tissues to represent B-cell responses to chemical insult. In vitro cell cultures
of thymus, spleen, or lymph nodes are being utilized to investigate the relation-
ships between intermediary metabolism and T-cell or B-cell mitogenic responses.

I will continue to participate in a screening program for immunotoxic chemicals
by providing correlative evidence of metabolic derangement with immune dys-
function in specific populations of lymphoid cells and macrophages. Whenever
feasible and promising, mechanistic studies to elucidate the metabolic basis of
specific immunotoxicity will be pursued.

S IGNIFICANCE TO BIOMEDICAL RESEARCH AND THE PROGRAM OF THE INSTITUTE : Informa-
tion regarding the immunotoxicity of each chemical may be useful in therapeutic
intervention and will provide another sensitive measure of the potential
chemical hazard to man.



602



SMITHSONIAN SCIENCE INFORMATION EXCHANGE
PROJECT NUMBER (Oo MOT use this space)



U.S. DEPARTMENT OF

HEALTH AND HUMAN SERVICES

PUBLIC HEALTH SERVICE

NOTICE OF

INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER

Z01 ES 21023-01 CTEB



PERIOD COVERED

March 30, 1982 to July 30, 1982



TITLE OF PROJECT (80 characters or less)

A study of the effects of dimethyl methyl phosphonate on the reproductive
system of the Fischer 344 male rat



NAMES, LABORATORY AND INSTITUTE AFFILIATIONS, AND TITLES OF PRINCIPAL INVESTIGATORS AND ALL OTHER
PROFESSIONAL PERSONNEL ENGAGED ON THE PROJECT



PI:
Co-PI
Co-PI
Other



June K. Dunnick
Bhola N. Gupta
James C. Lamb, IV
Martha Harris
John A. Moore



Chemist
Pathologist
Research Biologist
Technical Supervisor
Chief, Systemic Tox.



TRIP


NIEHS


TRIP


NIEHS


TRIP


NIEHS


TRIP


NIEHS


TRIP


NIEHS



COOPERATING UNITS (if any)



lab/branch

Systemic Toxicology Branch, TRIP



INSTITUTE AND LOCATION

NIEHS, NIH, Research Triangle Park, NC



27709



TOTAL MANYEARS:

0.5



PROFESSIONAL;

0.5



OTHER:



CHECK APPROPRIATE BOX(ES)
G (a) HUMAN SUBJECTS

D (al) MINORS □ (a2) INTERVIEWS



n (b) HUMAN TISSUES



[%{c) NEITHER



SUMMARY OF WORK (200 words or less - underline keywords)

Dimethyl methyl phosphonate (DMMP) is a nerve gas simulant uied in the U.S.
Armed Forces. Mild testicular lesions v^ere diagnosed in the Fischer 344 male
rat after the 90-day subchronic study. This study is designed to further assess
the effects of DMMP on the reproductive system of the male rat. DMMP v^il1 be
administered by gavage for 90 days at 0, 250, 500, 1,000 and 2,000 mg/kg. On
day 84 the rats v^ill be mated. The female rats will be sacrificed 14 days after
mating and pups examined. Male reproductive organs v/ill be examined for sperm
morphology and counts; histopathology will be performed on the male reproductive
organs.



603



PHS-6040
(Rev. 2-81)



ZOl ES 21023-01 CTEB

PROJECT DESCRIPTION

OBJECTIVES : This study is designed to determine the effects of dimethyl methyl
phosphonate (DMMP) on the reproductive system of the male Fischer 344 rat.

METHODS EMPLOYED : Administration of DMMP by gavage for 13 weeks; mating trial;
determination of sperm morphology and epididymal sperm count; gross and histo-
pathology on male reproductive organs; hormone assays.

MAJOR FINDINGS AND PROPOSED COURSE : The studv is still in the dosing phase, and
effects on the male reproductive system will be measured in the next several
months.

SIGNIFICANCE TO BIOMEDICAL RESEARCH AND THE PROGRAM OF THE INSTITUTE : Dimethyl
methyl phosphonate (DMMP) is a nerve gas simulant used in the U.S. Armed Forces.
Current military uses of DMMP include: a simulant for anticholinesterases for
testing vapor Sc^mplers; and a simulant for suitability of filters and filter
canisters for military protective masks. Little information is available on the
toxicologic properties of DMMP, and the U.S. Armed Forces has asked the National
Toxicology Program to test this compound. This study is designed to test the
effects of DMMP on the reproductive system, and will serve as one part of the
NTP's overall assessment of DMMP. Other studies underway include a two year
bioassay in the Fischer 344 rat and B6C3Fi mouse.



604



SMITHSONIAN SCIENCE INFORMATION EXCHANGE
PROJECT NUMBER (Oo NOT use this space)



U.S. DEPARTMENT OF

HEALTH AND HUMAN SERVICES

PUBLIC HEALTH SERVICE

NOTICE V

INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER

Z01 ES 30100-03 CTEB



(5c'toberT 1981 to September 30, 1982



TITLE OF PROJECT (80 characters or less)



Toxic effects of 1 ,2-dibromo-3-chloropropane on the urogenital system



NAMES, LABORATORY AND INSTITUTE AFFILIATIONS, AND TITLES OF PRINCIPAL INVESTIGATORS AND ALL OTHER
PROFESSIONAL PERSONNEL ENGAGED ON THE PROJECT



P.I.: William M. Kluwe
Others: James C. Lamb, IV
Bhola N. Gupta



Pharmacologist, TRIP
Biologist, TRIP
Pathologist, TRIP



NIEHS
NIEHS
NIEHS



COOPERATING UNITS (if any)



lab/branch
TRIP, NIEHS



SECTION



Carcinog enesis and Toxicology Evaluation Branch



INSTITUTE AND LOCATION

NIEHS, NIH. Research Triangle Park,



NC 27709



TOTAL MANYEARS:

1-1/8



PROFESSIONAL:



AM



OTHER:



CHECK APPROPRIATE BOX(ES)
D (a) HUMAN SUBJECTS

D (al) MINORS D (a2) INTERVIEWS



n (b) HUMAN TISSUES



K] (c) NEITHER



SUMMARY OF WORK (200 words or less - underline keywords)

The acute and subchronic toxic effects of the pesticide 1 ,2-dibromo-3-chloro-
propane (DBCP) and structurally-related compounds are studied from functional
and mechanistic viewpoints. A reported chemo-sterilant in humans, DBCP is no
longer manufactured in the U.S., but its presence in ground water and on edible
imports and its illegal bulk transport into certain areas of the U.S. require
its further. tox.icological characterization. Effects of DBCP on hepatic , renal
and reproductive functions are evaluated at several dose levels, after various
treatment regimens and under differing conditions such as age, chemical or
physical stress and the like. The distribution and disposition of DBCP is
being studied in rats, as well as selected aspects of its metabolism and the
effects of metabolic modulation on DBCP toxicities.

Comparative toxicities of DBCP and its metabolites are being evaluated to
ascertain the toxic chemical moiety and to predict whether structurally
similar chemicals would produce the same toxic effects as DBCP.

605

PHS-6040
(Rev. 2-81)



ZOl ES 30100-03 CTF.B



PROJECT DESCRIPTION



METHODS EMPLOYED : Toxic effects are being studied in male and female Fischer 344
rats using a variety of functional, biochemical and pathological techniques.
Disposition, distribution and metabolism studies are conducted in, or with
tissues from, male Fischer 344 rats by standard techniques.

MAJOR FINDINGS AND PROPOSED COURSE : Acute intoxication with DBCP causes dose-
dependent injury to the kidney, testis, epididymis and liver. Effects on the
liver, epididymis and kidney appear to be reversible, but testicular damage is
progressive and may be irreversible following significant acute injury. The acute
toxic manifestations of DBCP treatment bear many similarities with the acute toxic
effects of the DBCP metabolites epi- and alpha-chlorohydrin and 6-chlorolactic
acid, but not with oxalic acid, another DBCP metabolite. These results suggest
that DBCP, epichlorohydrin and alpha-chlorohydrin may exert their effects via a
common pathophysiological mechanism. DBCP nephrotoxicity and testicular toxicity
is blunted by pretreatment with the microsomal enzyme inducer phenobarbital , but
enhanced by pretreatment with cobaltous chloride or by partial hepatectomy. DBCP
metabolism, therefore, appears to be involved in the expression of toxicity,
though the mechanism of metabolic modulation remains to be elucidated. DBCP is
detoxified by conjugation with hepatic glutathione, and the threshold acute toxic
dose of DBCP coincides with the dose that significantly depletes hepatic gluta-
thione. Immature rats (24 days old) are relatively resistant to the acute toxic
effects of DBCP. Repeated exposure to acutely less-than-toxic DBCP doses pro-
duces a transient period of infertility in male rats, but no change in epididymal
sperm number, motility or morphology. Future studies will continue to character-
ize the dose-response relationship for DBCP and examine cumulative toxic effects.
Pharmacokinetic studies will determine tissue repositories, the relationships of
metabolite patterns to tissue injuries and the propensity of DBCP or metabolites
to interact with genetic materials. The basis for resistance of young animals to
acute DBCP toxicity will be studied.

SIGNIFICANCE TO BIOMEDICAL RESEARCH AND THE PROGRAMS OF THE INSTITUTE : Character-
ization of the toxic effects of DBCP and elucidation of the mechanisms of action
of this and similar toxic halocarbon compounds will allow better estimates of
human risk to be made. Observance of reduced fertility at doses below those which
reduce sperm number suggest that sperm counts (currently used as an index of human
DBCP toxicity) may be inadequate to ensure safe human exposures. Similarities
between the toxic actions of DBCP, epi- and alpha-chlorohydrin indicate the possi-
bilities of "DBCP-like" effects for other chemicals that have similar structures.

PUBLICATIONS

Kluwe, W. M.: Acute Toxicities of 1 ,2-Dibromo-3-chloropropane in the Fischer 344
Male Rat. I. Dose-Response Relationships and Differences in Routes of Exposure.
Toxicol. Appl. Pharmacol. 59: 71-83, 1981.

Kluwe, W. M. : Acute Toxicities of 1 ,2-Dibromo-3-chloropropane in the Fischer 344
Male Rat. II. Development and Repair of the Renal, Epididymal, Testicular and
Hepatic Lesion i.' Toxicol. Appl. Pharmacol. 59: 84-95, 1981.

Kluwe, W. M., Greenwell, A. and Harrington, F. W.: Relationship of tissue non-
protein sulfhydryls to the acute toxic effects of 1 ,2-dibromo-3-chloropropane.
J. Pharmacol. Exp. Ther. 220: 399-405, 1982.

606



SMITHSONIAN SCIENCE INFORMATION EXCHANGE
PROJECT NUMBER (Oo NOT use this space)



U.S. DEPARTMENT OF

HEALTH AND HUMAN SERVICES

PUBLIC HEALTH SERVICE

NOTICE OF

INTRAHURAL RESEARCH PROJECT



PROJECT NUMBER



ZOl ES 30101-03 CTI.I3



PERIOD COVERED

October 1 , 1981 to Sept e mber 30,JI982_^

TITLE OF PROJECT (sO characters or less)

Renal function tests as indicators of nephrotoxicity.



NAMES, LABORATORY AND INSTITUTE AFFILIATIONS, AND TITLES OF PRINCIPAL INVESTIGATORS AND ALL OTHER
PROFESSIONAL PERSONNEL ENGAGED ON THE PROJECT



PI: William M. Kluwe



Pharmacologist, TRIP



NIEHS



COOPERATING UNITS (if any)



lab/branch
TRTP/NTP



SECTION

Carcinogenesis and Toxicology Evaluation Branch



INSTITUTE AND LOCATION

NIEHS, NIH, Research Triangle Park, NC



27709



TOTAL MANYEARS:



3/8



PROFESSIONAL:



1/8



1/4



CHECK APPROPRIATE B0X{ES)
D (a) HUMAN SUBJECTS

n {al) MINORS □ (a2) INTERVIEWS



n (b) HUMAN TISSUES



X] (c) NEITHER



SUMMARY OF WORK (200 words or less - underline keywords)

Renal function tests are conducted after single or multiple exposures of rats
to a variety of chemical agents to assess the sensitivities and versatilities
of the various tests for detecting subtle kidney injury. When appropriate,
new or improved methodologies are designed and evaluated. The development of
resistance to injury upon repeated chemical exposure and the effect of such
or other chemical stresses to the body are also studied.



607



PHS-6040
(Rev. 2-81)



ZOl ES 30101-03 CTEB



PROJECT DESCRIPTION



METHODS EMPLOYED : Following chemical exposure, the animals are placed in
metabol ic cages and urine is collected under appropriate conditions. Urinalyses
of varying completeness are performed to assess the functional status of the
kidney. Animals are sacrificed as necessary and the morphological appearance of
the kidney compared to the functional effects of chemical treatment.

MAJOR FINDINGS AND PROPOSED COURSE : Tests that measure functional capacities
of the kidney are the most sensitive and versatile indicators of subtle kidney
injury, while standard tests such as blood urea nitrogen and serum sodium
concentrations are relatively poor diagnostic tools.

The resistance to Mercuric chloride (HgClo) nephrotoxicity induced by repeated
treatment with HgCl^ does not extend to other chemical nephrotoxicants that
damage the same or aissimilar sections of the proximal tubule as does HgCl2.

Since many nephrotoxicants appear to interfere with protein handling by the
proximal tubules, comparisons are being made by electrophoretic methods of the
distribution of low molecular weight proteins from the urines of rats treated
with selected nephrotoxicants.

SIGNIFICANCE TO BIOMED ICAL RESEARCH AND THE PROGRAMS OF THE INSTITUTE :
Sensitive and appropriate endpoints,' as are being studied or developed in this
project, are essential to the conduct of meaningful toxicology studies, including
those conducted by the National Toxicology Program. In addition, sensitive
function tests may suggest mechanisms of nephrotoxic action.

PUBLICATIONS

Kluwe, W. M., Renal Function Tests as Indicators of Kidney Injury in Subacute
Toxicity Studies. Toxicol. Appl . Pharmacol. 57: 414-424, 1981.

Kluwe, W. M. : Rapid, Automated Measurements of Urinary Protein and Glucose
Concentrations. Pharmacol. Meth. 5: 395-400, 1981.

Kluwe, W. M. : The development of resistance to nephrotoxic insult: changes in
urine composition and kidney morphology upon repeated exposures to mercuric
chloride or biphenyl. J. Toxicol. Environ. Health, (in press), 1982.

Kluwe, W. M. : Developed resistance to mercuric chloride: failure to protect
against other nephrotoxicants. Toxicol. Lett, (in press), 1982.



608



SMITHSONIAN SCIENCE INFORMATION EXCHANGE
PROJECT NUMBER (Oo NOT use this space)



U.S. DEPARTMENT OF

HEALTH AND HUMAN SFRVICES

PUBLIC HEALTH SERVICE

NOTICE OF

INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER



ZOl ES 30102-03 CTEB



PERIOD COVERED

October 1, 1981 to September 30, 1982



TITLE OF PROJECT (80 characters or less)

Interactions between halogenated aliphatic chemicals and renal tubular cells
in vitro.



NAMES, LABORATORY AND INSTITUTE AFFILIATIONS, AND TITLES OF PRINCIPAL INVESTIGATORS AND ALL OTHER
PROFESSIONAL PERSONNEL ENGAGED ON THE PROJECT



P.I,



William M. Kluv\/e



Pharmacologist, TRIP



NIEHS



COOPERATING UNITS (if any)



lab/branch
TRTP/NIEHS



SECTION

Carcinogenesis and Toxicology Evaluation Branch



INSTITUTE AND LOCATION

NIEHS, NIH, Research Triangle Park, NC



27709



TOTAL MANYEARS:

3/8



PROFESSIONAL:



1/8



OTHER:



1/4



CHECK APPROPRIATE BOX(ES)
D (a) HUMAN SUBJECTS

D (al) MINORS □ (a2) INTERVIEWS



□ (b) HUMAN TISSUES



£1 (c) NEITHER



SUMMARY OF WORK (200 words or less - underline keywords)

Biochemical and physiological functions of renal cells are studied concurrent
v^ith, or following, in vitro exposure to nephrotoxic chemicals. The elicited
effects are correlated with morphological alterations to assess subcellular
mechanisms of action. Parallel studies are conducted in intact animals (in vivo



to assure the relevancy of the effects studied i_n vitro and to determine the
role of extrarenal factors in the development of chemical nephropathy.

The in vitro environment (e.g., pH, electrolytes, cofactors, energy substrates)
is manipulated to suggest biochemical mechanisms of action.



609



PHS-6040
(Rev. 2-81)



ZOl ES 30102-03 CTEB



PROJECT DESCRIPTION



METHODS EMPLOYED : Preparations of renal tissue (e.g., slices, isolated cells or
tubules) are combined with nephrotoxic chemicals in vitro and several functional
(e.g., electrolyte transport, energy metabolism) and biochemical parameters are
monitored. The major source of renal tissue is adult, male, F344 rats.

MAJOR FINDINGS AND PROPOSED COURSE : Many nephrotoxic halogenated aliphatic
chemicals cause rapid, concentration-dependent depressions of renal proximal
tubular cell function in vitro . The correlation between functional disturbances
produced in vitro and in vivo is good, though the effects are demonstrable
much more rapidly i£ vrTro than in vivo .

Future experiments will more closely evaluate the morphological effects produced
in vivo and in vitro at early time periods post-exposure and will ascertain the
earliest functional abnormalities produced in vivo . The metabolism and
degradation of toxic organohalides by kidney eel Is in vitro will also be studied
and the use of non-rodent (e.g., humans or other primates) tissues will be
explored.

SIGNIFICANCE TO BIOMEDICAL RESEARCH AND THE PROGRAMS OF THE INSTITUTE :
Many nephrotoxic halogenated aliphatic chemicals are commonly used as industrial
intermediates or as pesticides, resulting in widespread environmental distribution
and human exposure. By studying the interactions of these agents with the target
cells (kidney proximal tubular epithelium) in vitro , mechanisms of action can be
suggested, eventually leading to a better estimation of their potential for
human injury.

PUBLICATIONS

Kluwe, W. M.: Mechanisms of Acute Nephrotoxicity: Halogenated Aliphatic
Hydrocarbons. In Drugs and Environmental Toxicants , (G. A. Porter, ed.),
Elsevier-North Holland, 1982 (in press).

Kluwe, W. M. , Harrington, F. W. and Cooper, S. E.: Toxic effects of organo-
halide compounds on renal tubular cells in vivo and in vitro . J. Pharmacol. Exp.
Ther. (in press), 1982.



610



INTRAAGENCY AGREEMENT
222Y01-ES-20081

TITLE: Toxicology Data Management System

PROJECT OFFICER (NCI/NTP): Michael P. Dieter (NIEHS)

Albert J. Konvicka (NCTR)

DATE CONTRACT INITIATED: January 15, 1982

CURRENT ANNUAL LEVEL: $1,386,000

PROJECT DESCRIPTION

OBJECTIVES : NCTR will implement and maintain automated support of the informa-
tion processing requirements (Toxicology Data Management System [TDMS]) for the
animal bioassay portion of the NIEHS Toxicology Research and Testing Program,
a major operating component of the National Toxicology Program. TDMS will
replace the Carcinogenesis Bioassay Data System and then will serve as the
principal data base for all animal bioassays. To accomplish TDMS implementation,
it is necessary to purchase the appropriate hardware components and prepare and
validate the appropriate computer programs for data collection and data retrieval.
Data retrieval capability must be continually available for transmittal, exami-
nation, and utilization by NIEHS, NCTR, and participating contract laboratories.

METHODS EMPLOYED : Generally, for each contract laboratory, specific requirements
for implementation of the TDMS will be done in three phases: 1) introduction
of manual data collection forms; 2) installation of available microprocessor
terminals and software; and 3) complete automated support of all NIEHS bioassay
studies.

MAJOR FINDINGS AND PROPOSED COURSE : One contract laboratory, Southern Research
Institute, has served as a model for TDMS implementation. All of the bioassay
studies there are on-line; the data is being captured on terminals and trans-
mitted to the mainframe computer at NCTR. With the assistance of Southern
Research Institute systems development for animal room data, toxicology data, and
pathology have been completed and can now be used by other contract labs.
Reports suitable for contract lab usage and others designed for NIEHS usage
(summaries of the data) have been developed and verified. Suitable storage and
retrieval, verification, and user authorization systems for the computer-stored
data have been developed.

Four other contract laboratories. Battel le-Columbus, Microbiological Associates,
E.G. and G. Mason, and International Research and Development Corp., have been
selected for TDMS and are using manual forms to facilitate computer entry
when appropriate. These labs have now received the necessary hardware and will
begin automated data entry this fiscal year. As chronic starts ensue at the
remaining contract labs similar steps for automation will be employed.

Additional hardware for contract labs and for NIEHS have been ordered. Installa-
tion of this equipment will permit direct data access by NIEHS scientists and
communication between NIEHS and contract labs. A query language processor
system is proposed to enable NIEHS to examine the data arranged in various
desired formats.



611



Successful completion of the above phases will enable NIEHS to collect all types
of prechronic data at all of the laboratories.

SIGNIFICANCE TO BIOMEDICAL RESEARCH AND TO THE PROGRAM OF THE INSTITUTE :
Implementation of TDMS will permit rapid management decisions for contract
operations, improve the accuracy and uniformity of data collection, and enable
better comparisons with a historical data base of toxicology and carcinogenicity,
These improvements will enhance the quality of the data on each chemical tested
that will ultimately be utilized as guidelines for evaluating potential human
risk.



61 2-



BATTELLE COLUMBUS LABORATORIES - Columbus, Ohio 43201
NOl-ES-8-2151

TITLE: Comparative Carcinogenicity and Toxicity Studies of Selected Environmental
Chemicals in Laboratory Animals Exposed During Pre- and Postnatal Life

CONTRACTOR'S PROJECT DIRECTOR: Arthur C. Peters, D.V.M.

PROJECT OFFICER (NIEHS): Rajendra S. Chhabra, Ph.D., Supervisory Pharmacologist,



Online LibraryNational Institute of Environmental Health ScienceAnnual report : National Institute of Environmental Health Sciences (Volume 1982) → online text (page 55 of 90)