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NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES



FY 1984 INTRAMURAL RESEARCH PROJECTS A^iutl ffM^'
October 1, 1983 through September 30, 1984






•^jQ-



f'?-



CONTENTS

Office of Health Hazard Assessment 1

INTRAMURAL RESEARCH PROGRAM

Laboratory of Behavioral and Neurological Toxicology U

Laboratory of Genetics 29

Laboratory of Molecular Biophysics 67

Laboratory of Pharmacology 93

Laboratory of Pulmonary Function and Toxicology 109

Laboratory of Reproductive and Developmental Toxicology . . 127

Comparative Medicine Branch 141

TOXICOLOGY RESEARCH AND TESTING PROGRAM

Carcinogenesis and Toxicology Evaluation Branch 147

Cellular and Genetic Toxicology Branch 159

Chemical Pathology Branch 177

Program Resources Branch 183

Systemic Toxicology Branch 187

BIOMETRY AND RISK ASSESSMENT PROGRAM

Biometry and Risk Assessment Program, Office of the Director .... 211

Epidemiology Branch 213

Statistics and Biomathematics Branch 221

INTRAMURAL PROJECT NUMBER LISTING ii



INTRAMURAL PROJECT NUMBER LISTING



ZOl ES 10003-05 LMB
ZOl ES 10004-05 LMB
ZOl ES 10007-04 LMB
ZOl ES 10012-02 LMB
ZOl ES 20003-11 OHHA
ZOl ES 20007-07 OHHA
ZOl ES 20008-07 OHHA
ZOl ES 20011-04 OHHA
ZOl ES 20014-01 OHHA
ZOl ES 20015-01 OHHA
ZOl ES 20016-01 OHHA
ZOl ES 21001-04 CTEB
ZOl ES 21003-04 STB
ZOl ES 21004-04 STB
ZOl ES 21009-03 STB
ZOl ES 21012-03 CGTB
ZOl ES 21013-03 CGTB
ZOl ES 21014-03 CGTB
ZOl ES 21016-03 CGTB
ZOl ES 21024-03 STB
ZOl ES 21025-03 STB
ZOl ES 21026-03 STB
ZOl ES 21028-03 CGTB
ZOl ES 21029-02 STB
ZOl ES 21030-02 CTEB
ZOl ES 21036-02 STB
ZOl ES 21038-02 STB
ZOl ES 21042-02 STB
ZOl ES 21043-02 STB
ZOl ES 21045-02 CGTB
ZOl ES 21046-01 STB
ZOl ES 21047-01 CPB
ZOl ES 21048-01 CGTB
ZOl ES 21049-02 CGTB
ZOl ES 21050-01 PRB
ZOl ES 21051-01 CGTB
ZOl ES 21052-02 CGTB
ZOl ES 21053-01 CGTB
ZOl ES 21054-01 CGTB
ZOl ES 21058-02 CGTB
ZOl ES 21061-02 CTEB
ZOl ES 21062-02 CTEB
ZOl ES 21063-02 CTEB
ZOl ES 21064-02 CPB
ZOl ES 21065-02 CPB
ZOl ES 21066-02 CPB
ZOl ES 21069-01 STB
ZOl ES 21070-01 STB
ZOl ES 21071-01 STB
ZOl ES 21072-01 STB



ZOl ES 21073-01 STB
ZOl ES 21075-01 STB
ZOl ES 21076-01 CTEB
ZOl ES 21077-01 CTEB
ZOl ES 21078-01 CTEB
ZOl ES 21079-01 CTEB
ZOl ES 22102-03 CMB
ZOl ES 22104-01 CMB
ZOl ES 22105-01 CMB
ZOl ES 25001-07 LPFT
ZOl ES 25002-07 LPFT
ZOl ES 25007-06 LPFT
ZOl ES 25008-06 LPFT
ZOl ES 25009-05 LPFT
ZOl ES 25012-05 LMB
ZOl ES 25014-02 LPFT
ZOl ES 25017-02 LPFT
ZOl ES 25019-02 LBNT
ZOl ES 25020-02 LPFT
ZOl ES 25021-01 LPFT
ZOl ES 25022-01 LPFT
ZOl ES 25023-01 LPFT
ZOl ES 25024-01 LPFT
ZOl ES 25025-01 LPFT
ZOl ES 25026-01 LPFT
ZOl ES 25027-01 LPFT
ZOl ES 25028-01 LPFT
ZOl ES 30003-13 LMB
ZOl ES 30015-10 LMB
ZOl ES 30020-13 LMB
ZOl ES 30034-08 LMB
ZOl ES 30044-08 STB
ZOl ES 30050-08 LMB
ZOl ES 30051-08 LMB
ZOl ES 30064-07 LMB
ZOl ES 30065-07 LMB
ZOl ES 30066-08 LMB
ZOl ES 30100-05 CTEB
ZOl ES 30106-10 STB
ZOl ES 35005-05 LP
ZOl ES 40004-07 SBB
ZOl ES 40005-07 SBB
ZOl ES 41001-10 SBB
ZOl ES 43001-12 EB
ZOl ES 43002-08 EB
ZOl ES 43004-06 EB
ZOl ES 43008-05 EB
ZOl ES 43009-01 BRAP
ZOl ES 44002-09 SBB
ZOl ES 44003-07 EB
ZOl ES 45001-04 SBB
ZOl ES 46001-01 EB
ZOl ES 50005-10 LBNT
ZOl ES 50015-10 LBNT



m



ZOl ES 50038-06 LBNT
ZOl ES 50046-06 LMB
ZOl ES 50076-03 LBNT
ZOl ES 50077-02 LMB
ZOl ES 50078-02 LMB
ZOl ES 50079-02 LMB
ZOl ES 50080-02 LMB
ZOl ES 50081-02 LMB
ZOl ES 50082-01 LMB
ZOl ES 60098-05 LG
ZOl ES 60099-05 LG
ZOl ES 60102-06 CGTB
ZOl ES 60111-05 LG
ZOl ES 60113-05 LG
ZOl ES 60122-05 CGTB
ZOl ES 60128-04 CGTB
ZOl ES 60130-03 LG
ZOl ES 60132-04 LG
ZOl ES 60136-03 LG
ZOl ES 60143-02 LG
ZOl ES 60145-02 LG
ZOl ES 60146-02 LG
ZOl ES 60147-01 LG
ZOl ES 60148-01 LG
ZOl ES 60149-01 LG
ZOl ES 60150-01 LG
ZOl ES 60151-01 LG
ZOl ES 61005-05 LG
ZOl ES 61011-05 LG
ZOl ES 61018-04 LG
ZOl ES 61019-04 LG
ZOl ES 61021-03 LG
ZOl ES 61022-03 LG
ZOl ES 61023-02 LG
ZOl ES 61024-02 LG
ZOl ES 61025-02 LG
ZOl ES 61026-02 LG
ZOl ES 61027-02 LG
ZOl ES 61028-02 LG
ZOl ES 61029-02 LG
ZOl ES 61030-01 LG
ZOl ES 61031-01 LG
ZOl ES 61032-01 LG
ZOl ES 61033-01 LG
ZOl ES 65021-12 LG
ZOl ES 65029-03 LG
ZOl ES 65032-02 LG
ZOl ES 65033-01 LG
ZOl ES 70010-08 LRDT
ZOl ES 70015-01 LRDT
ZOl ES 70060-11 LRDT
ZOl ES 70065-08 LRDT
ZOl ES 70067-01 LRDT
ZOl ES 70069-02 LRDT



IV



ZOl ES 70075-01 LRDT
ZOl ES 70078-01 LRDT
ZOl ES 70080-11 LRDT
ZOl ES 70085-07 LRDT
ZOl ES 70090-01 LRDT
ZOl ES 70092-01 LRDT
ZOl ES 70132-05 LP
ZOl ES 70200-10 LP
ZOl ES 80001-12 LP
ZOl ES 80002-13 LP
ZOl ES 80003-10 LP
ZOl ES 80007-13 LP
ZOl ES 80008-10 LMB
ZOl ES 80031-08 LP
ZOl ES 80032-07 LP
ZOl ES 80035-08 LMB
ZOl ES 80038-01 LP
ZOl ES 80039-01 LP
ZOl ES 80040-01 LP
ZOl ES 80041-01 LP
ZOl ES 90030-04 LBNT
ZOl ES 90031-03 LBNT
ZOl ES 90033-02 LBNT
ZOl ES 90034-01 LBNT
ZOl ES 90035-01 LBNT
ZOl ES 90036-01 LBNT
ZOl ES 90037-01 LBNT
ZOl ES 90038-01 LBNT
ZOl ES 90039-01 LBNT
ZOl ES 90040-01 LBNT



OFFICE OF HEALTH HAZARD ASSESSMENT



DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER



ZOl ES 20003-11 OHHA



PERIOD COVERED

October 1, 1983, to September 30, 1984



TITLE OF PROJECT (80 characters or less. Title must tit on one Ime between the borders.)

Preventive Surveillance of Environnental Chemicals for Toxic Potential



PRINCIPAL INVESTIGATOR (List other professional personnel below the Principal Investigator.) (Name, title, laboratory, and institute affiliation)



PI: Herbert S. Posner
Others: Wil liam Jurgelski , Jr.
Warren T. Piver
Naomi Jean Bernheim
Errol Zeiger
Barry H. Mar'golis
Jeanne Rimpo



Pharmacologist OHHA NIEHS

Medical Officer OHHA NIEHS

Chemical Engineer OHHA NIEHS

Microbiologist OHHA NIEHS

Microbiologist TRTP NIEHS
Mathematical Statistician BRAP NIEHS

Technical Staff Member BRAP NIEHS



COOPERATING UNITS (if any)



Cellular Genetic and Toxicology Branch, TRTP/NIEHS
Statistics and Biomathematics Branch, BRAP/NIEHS



LAB/BRANCH

Office of the Director (OD)



SECTION

Office of Health Hazard Assessment (OHHA)



INSTITUTE AND LOCATION

NIEHS, NIH, Research Triangle Park, N. C. 27709



TOTAL MAN-YEARS:



1.3



PROFESSIONAL;



1.2



0.1



CHECK APPROPRIATE BOX(ES)

D (a) Human subjects
S (a1) Minors
n (a2) Interviews



n (b) Human tissues D (c) Neither



SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space provided )

The relationship of chemical structure to mutagenicity in Salmonella is being
examined using data provided by the National Toxicology Program. The first set
of compounds considered are the nitro-compounds and their homologs which do not
contain a nitro- group.

Examination of the structures of the nitro-compounds already tested and selected
for testing aided in proposing 52 additional compounds for testing, about 60% of
which were selected. Several treatments of the mutagenicity data have been
developed to compare a broad spectrum of observed activities. Some of
the findings can be summarized as follows. Primary nitroalkanes gave the lowest
mutagenicity rates. The secondary nitroalkane, 2-nitropropane, however, yielded
low but significant mutagenicity rates. Nitrobenzene was considered non-
mutagenic. The trisubstituted, monocyclic aromatic compounds contained a
greater number of compounds in the more mutagenic ranges than did the group of
disubstituted derivatives. The sets of di- and trisubstituted compounds had the
greatest numbers of representatives tested. With one exception, di- and
trinitro-, tetrasubstituted monocyclic aromatic compounds were rather mutagenic.
No mononitro-, tetrasubstituted derivatives have yet been tested. Some of the
penta- and hexasubstituted compounds yielded the most variable data. As expected,
some of the polycyclic aromatic and heterocyclic compounds were highly mutagenic
A homologous set of compounds that did not contain the nitro- group yielded
mainly negative results or the compounds were weaker mutagens than their homologs

A review of the hazards of methanol in individuals through nineteen years-of-age
has been completed.



PHS 6040 (Rev. 1/84)



GPO 904-917



DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER

ZOl ES 20007-07 OHHA



PERIOD COVERS) ,„-^

October T, 1983, to September 30, 1984



TITLE OF PROJECT (80 characters or less. Title must tit on one line between the borders.)



itification and Health Hazard Evaluation of Industrial and Food Chemicals



PRINCIPAL INVESTIGATOR (List other prolessional personnel below the Prmcioal Investigator ) (Name, title, laboratory and institute atlihation)

"-■■"-■ - ' ■ ^ Medical Officer OHHA WIEHS



PI;
Others:



William Jurgelski, Jr.
Hans L. Falk

Herbert S. Posner
Jean N. Bernheim
Warren Piver
David Pasquini
Larry Laird



Associate Director for OHHA NIEHS

Health Hazard Assessment

Pharmacologist OHHA NIEHS

Microbioloqist OHHA NIEHS

Chemical Engineer OHHA NIEHS

Air and Ind. Hyg. Engr. RTI

Engineer RTI



COOPERATING UNITS (it any)



Laboratory of Reproductive and Developmental Toxicology (LRDT/NIEHS)



LAB/BRANCH

Office of the Director (OD)



SECTION

Office of Health Hazard Assessment (OHHA)



INSTITUTE AND LOCATION

NIEHS, NIH, Research Triangle Park, North Carolina 27709



TOTAL MAN-YEARS;



0.7



PROFESSIONAL



0.7



0.0



CHECK APPROPRIATE BOX(ES)

D (a) Human subjects
D (a1) Minors
D (a2) Interviews



G (b) Human tissues 2j (c) Neither



SUMMARY OF WORK (Use standard unreduced type Do not exceed the space provided j

One of two reviews on methanol toxicity (Methanol as a Pediatric Toxin) ini-
tiated in collaboration with Dr. H. Posner, has been completed and is being
readied for submission to an appropriate journal.

An in-house review of chemical hazards in the microelectronics industry was
completed.

Two new projects have been initiated:

1. A comparison of structure and function at the organ and system levels
between the human and appropriate laboratory animals to permit selection
of models for the normal and impaired human in toxicity evaluation of
physical and chemical environmental agents, and

2. The development of guidelines that will permit clinicians to differen-
tiate a disease with a chemical or physical etiology from those with an
infectious or genetic causation.



PHS 6040 (Rev. 1/84)



DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER



ZOl ES 20008-07 OHHA



PERIOD COVERED

October 1. 1983. to Seotember 30. 1984



TITLE OF PROJECT (80 characters or less. Title must lit on one line between the borders.)

The Marsupial Model in the Identification and Evaluation of Environmental Toxins



PRINCIPAL INVESTIGATOR (List other professional personnel beiow the Principal Investigator.) (Name, title, laboratory, and institute affiliation)

PI: William Jurgelski, Jr. Medical Officer OHHA NIEHS



COOPERATING UNITS (if any)

Office of Health Hazard Assessment



LAB/BRANCH

Office nf the nirprtnr (OP)



SECTION

Off ire nf Hpalth H^7ard Aq';p<;c;!npnt (OHHA)



INSTITUTE AND LOCATION

MTFHS, NTH, Rp'^parrh Tri anni p Park, M. P.. ?77nQ



TOTAL MAN-YEARS;



0-^



PROFESSIONAL:



_Q_L



n.n



CHECK APPROPRIATE BOX(ES)

D (a) Human subjects D (b) Human tissues □ (c) Neither

D (a1) Minors
D (a2) Interviews



SUMMARY OF WORK (Use standard unreduced type Do not exceed the space provided.)

An invited review describing the use of the marsupial as a biomedical model is
in preparation.

The invited review on the marsupial as a model in space biology is nearing
completion.

Upon publication of the above papers, this project will be terminated. Future
requests for information on the marsupial model will be considered as part of
the project on Identification and Health Hazard Evaluation of Industrial and
Food Chemicals. (201 ES 20007-07 OHHA).



PHS 6040 (Rev, 1/84)



GPO 904-917



DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER



Z01 ES 20011-04 OHHA



PERIOD COVERED

October 1, 1983, to September 30, 1984



TITLE OF PROJECT (30 characters or less Title must tit on one line betweert the borders.)

Comprehensive Evaluations of Biological Effects of Chemicals on Health



PRINCIPAL INVESTIGATOR (List other professional personnel below the Principal Investigator j (Name, title, laboratory, and institute atliliation)

PI: Velimir B. Vouk

Warren T. Piver
Others: William Jurgelski , Jr.

Herbert S. Posner

Janet Guthrie

Maomi Jean Bernheim Microbiologist



Visiting Scienti


St


OHHA


NIEHS


Chemical Enginer




OHHA


NIEHS


Medical Officer




OHHA


NIEHS


Pharmacologist




OHHA


NIEHS


Microbiologist




OHHA


NIEHS



OHHA NIEHS



COOPERATING UNITS (it any)

Biometry and Risk Assessment Program (BRAP/NIEHS) , Laboratory of Reproductive and
Developmental Toxicoology (LRDT/NIEHS) , WHO/IPCS Inter-Regional Research Unit
(IRRU) at NIEHS and some 20 research institutions in the USA and other countries.



LAB/BRANCH

Office of the Director (OP)



SECTION

Office of Health Hazard Assessment (OHHA)



INSTITUTE AND LOCATION

NIEHS. NIH. Research Trianole Park, N. C,



27709



TOTAL MAN-YEARS:



3.3



PROFESSIONAL:



2.0



1.3



CHECK APPROPRIATE BOXiES)

D (a) Human subjects
n (a1) Minors
D (a2) Interviews



n (b) Human tissues S (c) Neither



SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space orovided.)

During the year under review, the emphasis has been on methods for evaluating
complex mixtures and for estimating chemical exposure and quantifying risks of
chemical injury. Other activities included compiling monographs on chemicals
selected for testing by the National Toxicology Program (NTP), evaluating expo-
sure to and risks of ethylene dibromide (EDB), enumerating the hazards of sodium
azide (the proposed inflator of air bags used as passive restraints in
automobiles), and a compilation of all known work on thirty air pollutants regu-
lated by the Environmental P>otection Agency (EPA).



PHS 6040 (Rev 1/84)



DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER

Z01 ES 20014-01 OHHA



PERIOD COVERED

October 1, 1983, to September 30, 1984



TITLE OF PROJECT (80 characters or less. Title must lit on one line between the boraers.)

SGOMSEC Meeting on Method Development for Chemical Mixtures



PRINCIPAL INVESTIGATOR (List other prolessional personnel below the Principal Investigator.) (Name, title, laboratory, and institute affiliation)

PI: Warren T. Piver Chemical Enqineer OHHA NIEHS



COOPERATING UNITS (if any)



LAB/BRANCH

Office of the Director (OD)



SECTION

Office of Health Hazard Assessment (OHHA)



INSTITUTE AND LOCATION

NIEHS, NIH, Research Triangle Park, N. C. 27709



TOTAL MAN-YEARS:



,15



PROFESSIONAL:



.15



0.0



CHECK APPROPRIATE BOX(ES)

D (a) Human subjects
D (a1) Minors
n (a2) Interviews



U (b) Human tissues 3 (c) Neither



SUMMARY OF WORK (Use standard unreaucea type. Do not exceed the space provided )

The Scientific Group on Methodoloaies and Safety Evaluation of Chemicals
(SGOMSEC) held its 3rd Workshop in August 1983 in Guildford, U.K., to develop
test methodologies for chemical mixtures. For the section of the Workshop on
Evaluation of Mixtures, a manuscript was prepared on predicting concentrations
of air pollutants.

The manuscript reviewed the meteorology and atmospheric chemistry of photochemi-
cal smog and the mathematical models used to predict ground level concentrations
of pollutants. From this review, it was recommended that technigues be developed
to measure the variability of velocity fields and dispersion coefficients
for long-range transport of atmospheric pollutants and the measurement of tran-
sient free radicals and other very reactive chemicals that participate in the
atmospheric reaction of photochemical smog to measure the variability. In addi-
tion, it was recommended that methods be developed to determine when simple
models and single chemical models can be used as surrogates for predicting con-
centration profiles for chemical mixtures.



PHS 6040 (Rev. 1/84)



PROJECT NUMBER
DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE

NOTICE OF INTRAMURAL RESEARCH PROJECT \Z.0^ ES 20015-01 OHHA



PERIOD COVERED

October 1, 1983, to September 30, 1984



TITLE OF PROJECT (80 characters or less. Title must tit on one line between ttie borders.)

Estination of Pollutant Concentrations in Air and Ground Waters



PRINCIPAL INVESTIGATOR (List other professional personnel below the Principal Investigator.) (Name, title, laboratory, and institute alliliation)

PI: VJarren T. Piver Chemical Engineer OHHA NIEHS

Others: F. Thomas Lindstrom Associate Professor Oregon State Univ;

Department of Mathematics Corvallis, Oregon

Lai la Moustafa IPCS-IRRU WHO



COOPERATING UNITS (it any)



LAB/BRANCH

Office of the Director (OD)



SECTION

Office of Health Hazard Assessment (OHHA)



INSTITUTE AND LOCATION

NIEHS, NIH, Research Triangle Park, M. C. 27709



TOTAL MAN-YEARS;

1.0



PROFESSIONAL:

1.0



0.0



CHECK APPROPRIATE BOX(ES)

n (a) Human subjects D (b) Human tissues B (c) Neither

D (a1) Minors
n (a2) Interviews



SUMMARY OF WORK (Use standard unreduced type Do not exceed the space provided.)

(1) A numerical procedure has been developed to describe the simultaneous
transport of heat, chemical mass, and soil moisture in unsaturated soils. The
deterministic model has been used to simulate transport of PCBs through dif-
ferent soils during light and moderate rain over 60 days. For unreactive chemi-
cals, transport strongly depends on hydrodynamics and adsorptivities to different
soil components.

(2) In conjunction with an Interregional Research Unit of the WHO/UMEP/ILO
International Programme on Chemical Safety (IPCS), a workshop is being planned
for May 1985. The workshop has three major objectives: (a) to review current
knowledge on groundwater contamination; (b) to review current knowledge on the
adverse effects of individual chemicals and chemical mixtures observed in ground
water; and, (c) to provide guidance to Member States confronted with groundwater
contamination and decontamination problems.

(3) For the 3rd Workshop of the Scientific Group on Methodologies and Safety
Evaluation of Chemicals (SGOMSEC) to develop methods for testing chemical mix-
tures, a manuscript was prepared that reviewed and analyzed mathematical models
used to predict ground level concentrations of atmospheric pollutants during
photochemical smog incidents.



PHS 6040 (Rev. 1/84) O - GPO 904-917



DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER

Z01 ES 20016-01 OHHA



PERIOD COVERED

October 1, 1983, to September 30, 1984



TITLE OF PROJECT (80 characters or less. Title must lit on one line between the boraers.)

Groundwater Quality Workshop



PRINCIPAL INVESTIGATOR (List other professional personnel below the Principal Investigator ) (Name, title, laboratory, and institute afliliation)

PI: Warren T. Piver Chemical Engineer OHHA NIEHS

Others: Laila Moustafa IPCS-IRRU WHO



COOPERATING UNITS (il any)



LAB/BRANCH

Office of the Director (OD)



SECTION

Office of Health Hazard Assessment (OHHA)



INSTITUTE AND LOCATION

NIEHS, NIH, Research Triangle Park, N. C. 27709



TOTAL MAN-YEARS:



PROFESSIONAL:



0.25



0.25



0.0



CHECK APPROPRIATE BOX(ES)

D (a) Human subjects
n (a1) Minors
n (a2) Interviews



□ (b) Human tissues G (c) Neither



SUMMARY OF WORK (Use stanaard unreauced type Do not exceed the space provided )

In conjunction with the IPCS of the WHO, a Workshop is being planned for May
1985. The Workshop is designed to accomplish three major purposes:

1) review basic knowledge on groundwater contamination from different
sources, identify capabilities and limitations of available methods for
measuring groundwater quality and predicting fate of mixtures of con-
taminants, and recommend neeeded research programs;

2) review basic knowledge on the toxic effects of individual chemicals and
chemical mixtures observed in groundwater and recommend needed research
programs; and

3) provide experience and guidance to ilember States confronted with
groundwater contamination and rehabilitation problems by analysis of
actual contamination incidents.



PHS 6040 (Rev. 1/84)



LABORATORY OF BEHAVIORAL AND NEUROLOGICAL TOXICOLOGY



n



1 PROJECT rjU.MBER
DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE 1

NOTICE OF INTRAMURAL RESEARCH PROJECT j

IZOl ES 25019-02 LBNT



PERIOD COVERED



October 1. 1983 to September 30. 1984



TITLE OF PROJECT (80 characters or less. Title must tit on one line between the borders I

Physalaemin-like Peptide in Mammalian Tissue



PRINCIPAL INVESTIGATOR (List other prolessional personnel below the Principal Investigator I iName. title, laborator/. and institute affiliation!

PI: Lawrence H. Lazarus Research Chemist LBNT NIEHS

Others: W. E. Wilson Research Chemist

B. J. Irons Biological Technician
0. Hernadez Research Chemist



LBNT


NIEHS


LBNT


NIEHS


LEC


NIEHS



COOPERATING UNITS (if any)

University of North Carolina, Chapel Hill
University of Rome, Italy



LAB/BRANCH

Laboratory of Behavioral and Neurological Toxicology



Peptide Neurochemistry



INSTITUTE AND LOCATION



IIEHS. NTH. Research Trianglp Park, NC ?77nq



TOTAL MAN-YEARS;



PROFESSIONAL:



CHECK APPROPRIATE BOX{ES)

n (a) Human subjects D (b) Human tissues i3 (c) Neither

D (a1) Minors
D (a2) Interviews



SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space orovided.)

This project is continuing under Project Number: ZOl ES 90034-01, Title: Rabbit
Stomach Peptide [Physalaemin-like Material (PLIM)] in Mammalian Tissue.



PHS 6040 (Rev. 1/84) TT



DEPARTMENT OF HEALTH AND HUWAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT rjUMBER



ZOl ES 50005-10 LBNT



PERIOD COVERED

October 1 , 1983 to September 30, 1984



TITLE OF PROJECT (80 characters or less. Title must tit on one tine between the Ooraers.)

Effects of Noise and Ototoxic Agents on Energy Balance and Metabolism in Cochlea



PRINCIPAL INVESTIGATOR lUst other proressional personnel below the Principal Investigator.) {Name, title, laboratory, ana institute affiliation)

PI: Teruzo Konishi Medical Officer (Res.) LBNT NIEHS



Others: J. Muratsuka



Visiting Fellow



LBNT



NIEHS



COOPERATING UNITS (if any)



LAB/BRANCH

Laboratory of Behavioral and Neurological Toxicology



SECTION

Neurophysiology



INSTITUTE AND LOCATION

NIEHS, NIH, Research Triangle Park, NC 27709



TOTAL MAN-YEARS-



1.5



PROFESSIONAL:
1.1



0.4



CHECK APPROPRIATE BOX(ES)

□ (a) Human subjects
D (a1) Minors
n (a2) Interviews



□ (b) Human tissues



JC (c) Neither



SUMMARY OF WORK (Use stanaard unreOucea type.. Do not exceed the space proviaea )



The perilymphatic perfu
(ImM) was employed in g
the cochlear potentials
measured in both contro
cation of bromate resul
and sound evoked respon
observed. A substantia
increase in sodium cone
indicated that the prim
and in advanced stage o
a further suppression o



sion with artificial perilymph containing sodium bromate
uinea pigs to study the ototoxity of bromate. Changes in
and electrolyte concentrations in the endolymph were
1 and experimental perfusions. The perilymphatic appli-
ted in a gradual suppression of the endocochlear potential
ses. The recovery of the cochlear potentials was not
1 decrease in potassium and chloride concentrations and
entration were observed in the endolymph. Our results
ary site of action of bromate was on the stria vascularis
f intoxication bromate might affect the hair cells, causing
f the hair cell responses.



PHS 6040 (Rev. 1/84)



14



GPO 90a 917



DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER



ZOl ES 50015-10 LBNT



PERIOD COVERED

October 1, 1983 to September 30, 1984



TITLE OF PROJECT (80 characters or less. Title must lit on one line between the borders /

Effects of Microwaves on Neural Response



PRINCIPAL INVESTIGATOR (List other professional personnel below the Principal Investigator I (Name, title, laboratory, and institute atliliation)


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Online LibraryNational Institute of Environmental Health ScienceAnnual report : National Institute of Environmental Health Sciences (Volume 1984 pt.2) → online text (page 1 of 19)