National Institute of Environmental Health Science.

Annual report : National Institute of Environmental Health Sciences (Volume 1985) online

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systems. Ms. Willia Green, the OPPE stay-in-schooler, also has provided
invaluable assistance and has proved to be a quick study with regard to new
information systems.


Final Note

Early in the fiscal year, I (George Kingman, Director, OPPE) announced my
intention to retire from Federal Service in the Spring of 1986. This will
bring to a close almost thirty years of service on the staff of the National
Institutes of Health and nineteen years with the National Institute of
Environment Health Sciences. It has been a great privilege to have served
throughout three decades of exciting developments in biomedical research, and
almost two decades in the field of environmental health. This period has
spanned the terms of seven Presidents. While the field of environmental
health has matured greatly in the last twenty years, and moved center stage
in the arena of science and public policy, like the poet I believe "the
best is yet to come."

I owe a great debt to those with whom I have served over the years, and who
have helped me so much in my many different assignments. I will miss them











Summary Statement

The Office of Facilities Engineering (OFE) plans, directs, supervises and
coordinates all facilities activities including, but not limited to,
engineering design, inspection, construction, master planning, operation of
utility plants and systems, maintenance and repair of all real property
(buildings, grounds, surfaced areas, utility plants and systems),
maintenance of facility operations equipment and vehicles, fire prevention
and protection, custodial, refuse collection and disposal, supply and
storage of construction and operations materials, and other miscellaneous
facilities engineering services and operations.

At the direction of the Director, NIEHS, OFE performs non-facility
engineering mission support work including, but not limited to, security,
graphics, photography, and the design, fabrication, alteration and repair
of intramural scientific instrumentation.

The work at NIEHS provides national and international leadership for
similar installations throughout the world (grants and institutions),
therefore, the facilities and equipment are in the forefront as models for
use by research facilities outside of NIH, nationally and internationally.

Facilities :

OFE is responsible for the entire NIEHS facility comprised of 194,260
square feet of leased space, and 464,868 square feet of Government-owned
space. The North Campus site consists of 154,274 square feet in a complex
of 19 buildings, housing a staff in excess of 500 fulltime permanent

The new NIEHS administration, laboratory, and support facilities, now
complete, are on a 509-acre tract of land in the Research Triangle Park in
close proximity to the North Campus facilities. These new facilities are
now fully occupied. NIEHS will continue to occupy the North Campus
facilities, while "off-site" leased facilities will be relinquished, except
for warehouse space. The Extramural Program, presently located in the
Burden Creek Facility on South Campus is to be relocated to the North
Campus Facility.

Office Functional Sections :

OFE is divided into six functional sections under the Office of the Chief.
The Facilities Management Section is the coordination point for all service
requests providing planning/estimating, maintenance scheduling, material
expediting, shops materials and parts storage and disbursement services to
OFE. The Facilities Management Section maintains all work order, contract,
and manpower management records. The Engineering Design Section provides
architectural and engineering support required for planning new NIEHS
facilities, improvements, major repairs and alterations through in-house
design or contract with A/E firms. The group also provides architectural


and engineering support for the administration and inspection of NIEHS
construction performed under contract.

The Operations Section oversees operations and maintenance of the power
plant and building mechanical and electrical systems on the NIEHS South
Campus. The power plant houses two 40-million BTUH oil, coal, and
gas-fired boilers and two 2,500-ton water chillers. These systems are in
continuous operation and deliver the environmental control (heating,
cooling and humidity) to all facilities on the permanent site. Also,
leased facilities operations are managed by this section in concert with
the Facilities Management Section. The Maintenance Section provides shop
services to the Institute. This includes 3 units: electrical, carpentry,
and mechanical. Together these units respond to emergency repair calls,
make minor alterations, and otherwise perform maintenance, major equipment
preventive maintenance and repair.

The Instrumentation and Arts Section provides arts, graphics and
photographic services to Institute personnel as adjuncts to publications of
papers, conferences, seminars, and scientific exhibits. Additionally, the
section provides instrumentation fabrication services and also supports
repair and maintenance.

A new section, the Special Projects Section, was recently organized to
coordinate planning, design and construction of an addition to Building 101
and related site improvements and utilities systems expansion on South

Goals and Accomplishments :

In Fiscal Year 1985, OFE directed a major effort toward completing design
and construction of alterations to buildings on the North Campus. A major
renovation was completed in Building 15. The Laboratory of Behavioral &
Neurological Toxicology has moved a major part of its program into Building
15. Alterations are still going on in Building 6 to house the mass
spectrometry group of the Laboratory of Molecular Biophysics. Alterations
are underway in Buildings 2 and 3 to accommodate the Extramural Program.
Construction will begin soon on alterations in Building 10 to house the
Office of Administrative Management which currently occupies leased
facilities near the Research Triangle Park.

Construction is in progress to replace the patio tile at Building 101 on
the South Campus to eliminate serious construction flaws. Construction is
also underway to repair faulty flashing and roofing on Building 101.
Studies are underway to correct serious sound level problems in the air
conditioning systems in the laboratories; and control problems on the air
conditioning systems for the administrative areas.

OFE has begun to automate some of its administrative requirements. An
automated file system for key and lock controls has been implemented. A
program for procuring materials and services under the Record of Call
method has been developed and testing and evaluation will begin soon. An
inventory management system has been developed and there are various
automated procedures established and ready for testing which will


complement the current work order system. OFE has accomplished these new
procedures by contracting two program analysts and a data entry clerk
through the GSA contract with the Institute Computer Technologies Branch.
In addition, OFE has procured and taken delivery of a CPU as the base for
the automated system. Other hardware and software are pending delivery and
installation. Full operation is expected to begin by the end of the
current fiscal year.

A Preventive Maintenance equipment inventory has begun and is going well.
An award was made for this contract in December.

Future Branch Objectives :

During the next Fiscal Year, OFE will concentrate its efforts in the
following areas: (1) completion of alterations in buildings on North
Campus, (2) completion of a Program of Requirements and start of design
for additions to program and support facilities (Building 101 addition),
and (3) continuation of a contract effort to provide a comprehensive
preventive maintenance program for all physical facilities and equipment on
South Campus.

OFE recently awarded an Architectural/Engineering contract to develop a
Program of Requirements for additions to Building 101 and related support
facilities on the South Campus. A schedule has been established to prepare
construction plans and specifications, award construction contracts and
complete construction of the facilities in the spring of 1991. It has been
the intent of NIEHS in its long range plan to complete facilities on South
Campus to house all NIEHS activities on the one campus before the current
leases expire on North Campus expire in May 1991. The newly organized
Special Projects Section in OFE will direct all its attention to the
completion of the facilities within the established time schedule.

Efforts will continue in the area of automation for more effective and
efficient operation of OFE. The work order system is scheduled to be in
operation within the coming fiscal year and OFE has the lead in working out
the Record of Call procurement system for its application to the rest of
the Institute. The Preventive Maintenance system requirements will be
established as the equipment is inventoried and our analysts will be
preparing recommendations for the software to fulfill that need. As the
maintenance procedures are readied, following the inventory, many of those
service requirements will be scheduled and contracts established to perform
them. These procedures will significantly reduce the frequency and
magnitude of breakdown repair at our facility.






Summary Statement

The NIEHS Health and Safety Office is administratively located within the
Office of the Deputy Director and has broad responsibility for chemical and
radiation safety, physical safety, fire protection, emergency preparedness,
environmental protection and occupational health surveillance. The Health
and Safety Office conducts research studies and special investigations
relative to specific safety concerns.

Toxicological research laboratories pose unique health and safety problems
due to the great variety of chemicals and radioisotopes that may be used
and the non-routine nature of many laboratory procedures. The primary
emphasis of the NIEHS Health and Safety Office is to minimize exposures and
unsafe conditions through utilization of containment equipment, following
appropriate work practices and procedures and use of personal protective
equipment. The primary tools for accomplishing this objective are the
required hazardous agent safety protocol, employee training and programs
for information dissemination.

Programs for safe use of hazardous chemical agents are high priority at
NIEHS. There were approximately 132 active protocols for use of hazardous
chemicals in force during FY85. An important component of the Health and
Safety Program is routine surveys of all laboratories, shops and warehouses
on a quarterly basis. These surveys serve to identify potential hazards
and to initiate preventive actions as well as to maintain an awareness of
potential hazards. During FY85 a special survey of chemical storage prac-
tices was conducted and a set of guidelines developed and distributed to
all Laboratories and Branches.

Use of primary containment devices and other engineering control measures
is the preferred means of minimizing occupational exposures. All labora-
tory hoods, a total of 145, are inspected and their performance measured on
a quarterly basis. Information concerning deficient hoods is immediately
referred to the Office of Facilities Engineering for corrective action. In
addition to fume hoods, a total of 46 biological safety cabinets are in use
at NIEHS. All biological safety cabinets are tested and certified annually
by an independent testing firm.

During FY85 the Health and Safety Office expanded and improved programs for
monitoring occupational exposures. Routine sampling programs for organic
vapors in laboratories, shops and waste processing areas were expanded both
in frequency and extent of coverage. A special sampling program for for-
maldehyde exposures was completed and a routine formaldehyde monitoring
program established. Other special air sampling studies completed included
evaluation of wood dust exposures among animal bedding handlers and a study
of potential trichloroethylene exposures during administration of this com-
pound to test animals. A quality control program for the industrial
hygiene laboratory was initiated which includes written procedures, preven-
tive maintenance schedules for instrumentation, calibration procedures and
recordkeeping requirements. As a part of the quality control program,


NIEHS applied and was accepted as a participant in the NIOSH Proficiency
Analytical Testing Program (PAT) for organic solvents. The PAT program
will provide a good means of quality control for analytical procedures.

The primary emphasis of NIEHS health and safety programs is exposure pre-
vention through proper experimental design and use of laboratory contain-
ment equipment. Personnel protective equipment is used to supplement other
preventive measures. A written respiratory protection program has been
developed which includes initial selection criteria, qualitative fit
testing, training of new users and annual maintenance checks by the Health
and Safety Office. There were approximately 89 occasional users of respira-
tors at NIEHS during FY85.

Use of radioisotopes and radiation sources has become an integral part of
biomedical research. The Institutes' use of radioisotopes continues to
increase with over 200 active protocols for the use of radioactive material.
Approximately 1200 shipments of radioactive material were received in FY85
representing an increase of approximately 20% over FY84. The Institutes'
use of 32p nas continued to increase while the use of other isotopes
remained about the same as in FY84. In FY85 new procedures were established
to expedite the ordering of isotopes while at the same time assuring that
all radioactive material is properly accounted for.

Routine duties of the radiation protection program include monthly labora-
tory surveys, surveys of sealed sources, checking for contamination in
cases of suspected spills, receiving and distributing incoming isotopes,
calibration of radiation detection instruments, disposal of radioactive
wastes, bioassay procedures, monitoring of . personnel exposures and keeping
an inventory of all radioisotopes at the Institute. In addition to these
routine duties, special investigations are conducted to address specific
issues relative to NIEHS radiation safety programs. A two year study on
the fate of incinerated radionuclides was completed in FY85 and a
manuscript submitted for publication. New studies were initiated on the
dosimetry and calibration of beta emitting radioactive material. An extra-
polation chamber was used in conjunction with National Bureau of Standards
traceable beta sources to calibrate dosimeters and radiation detection
equipment. This study will continue in FY86 and will evaluate the exposures
of personnel handling beta emitters such as 32 P in various laboratory

The Health and Safety Office has responsibility for providing occupational
health services for NIEHS employees. Services are provided through an
interagency agreement with the PHS, Division of Federal Employee
Occupational Health. Services provided include emergency treatment,
periodic occupational health surveillance programs, preventive health
programs, health promotion and education programs. During FY85 an auto-
mated occupational safety and health data management system was fully
implemented and will provide integration of potential exposure infor-
mation with health surveillance data. A special project to develop a
surveillance program for laboratory animal allergies was initiated during
FY85. The initial implementation included a questionnaire to determine
allergy prevalence among NIEHS employees and initiation of an industrial
hygiene study to identify potential exposures to airborne allergens


during animal handling. Ifl FY85 an Employee Assistance Program was deve-
loped and initiated. This program will provide employes with assistance in
dealing with psychological or emotional problems potentially affecting work
performance. Great care has been taken to assure confidentiality of all
information from this program.

The Health and Safety Office continues to seek ways of improving the
Institutes' hazardous waste management programs. During FY85, an addi-
tional full time on-site hazardous waste chemist was added to assure the
timeliness of waste processing and to improve recordkeeping. The building
design of a new 5000 square foot waste processing facility was completed in
FY85 with construction to begin in FY86. An environmental impact
assessment for this building was completed and approved.

Safety and health training is an important component of the Institutes'
safety program. The Health and Safety Office offers a number of courses
for laboratory personnel including "General Laboratory Safety," and
"Introduction to Radiation Safety". Approximately 100 employees attend
each of these courses per year. A course syllabus was developed for the
General Laboratory Safety course. The syllabus will provide attendees
with excellent reference material which will supplement the Institutes'
Safety and Health Manual. In addition to the above laboratory safety cour-
ses, routinely scheduled courses in CPR, First Aid, and " Fire Extinguisher
Use" are made available to all interested NIEHS employees. The Health and
Safety Office also provides other special training as necessary. A one day
course in "Biosafety Awareness" was sponsored jointly with the NIH Division
of Safety in FY85 and had a total of 58 participants. Other special
training provided in FY85 included instruction in proper lifting techniques
for Comparative Medicine Branch personnel and use and care of compressed
gas cylinders for warehouse personnel.

Safety and Health programs and training for NIEHS employees other than
laboratory workers, such as shops and maintenance personnel, is an impor-
tant area of emphasis. Major new programs including confined space entry
and lockout/tagout procedures were developed and fully implemented during
FY85. Among other requirements, the confined space program requires Health
and Safety Office monitoring of all confined areas such as valve pits,
electrical pits and tanks for hazardous conditions on a routine basis and
before entry by maintenance personnel. Monthly safety training meetings for
Office of Facilities Engineering personnel continued in FY85 covering a
variety of topics.

Fire prevention and emergency preparedness continue to receive considerable
attention. During FY85 the Occupant Emergency Plan for Building 101 was
reviewed and updated and a plan developed for the warehouse and engineering
complex. Smoke detectors were added to the elevator lobby in Building 101
and plans for a public address system completed. Several new fire hydrants
were added for fire protection of NIEHS facilities. Safety and fire inspec-
tions of low hazard areas such as offices were expanded in FY85.

Responsibility for the Institutes' environmental protection programs reside
with the Health and Safety Office. During FY85 a test burn of the large
South Campus waste incinerator was completed. Test results demonstrated
compliance with North Carolina air pollution regulations. A detailed survey


of all NIEHS stsym drains and underground storage tanks was completed to
assure compliance with all applicable ground water regulations. During FY85,
a protocol for a detailed environmental audit was developed jointly with the
NIH Division of Safety.









Summary Statement

The NIEHS Library is the principal science reference resource for the
Institute. Library and information services include reference services, com-
puterized literature searching of bibliographic and scientific databases, main-
tenance of a collection of 700 periodical titles and 13,000 books on environ-
mental health, participation in a nation-wide network for interlibrary loan
and cataloging, procurement of 1,450 new books for the Library and the
laboratories, and publication of a monthly newsletter and the annual biblio-
graphy of publications by NIEHS personnel.

Reference/Literature Searching : The Library maintains one of the most advanced
computerized literature searching capabilities in the world, with access to more
than 200 databases covering subjects from toxicology to business administra-
tion. During FY85, Library personnel performed comprehensive multi-database
searches on over 1,100 topics. Most of the year the Reference Librarian posi-
tion was vacant, but during one three-month period 700 reference questions were
answered. The most heavily used databases continued to be TOXLINE, MEDLINE,
Toxicology Data Bank, Biological Abstracts, and Chemical Abstracts. Examples of
search requests include the following: comprehensive literature search on
methyl isocyanate for the International Office to respond to the Bhopal, India,
emergency and for TRTP to begin testing; comprehensive search on other recent
chemical emergencies for background briefing for Dr. Rail; comprehensive
searches on the relationship of high altitudes and cancer and on leukemia in
refinery workers for BRAP; searches on porphyrias and chemicals and on naturally
occurring toxicants in food; and numerous searches for toxicological information
on chemicals for TRTP. Library staff also began a project to provide training
to scientists who want to do their own computerized literature searches. Eleven
TRTP Chemical Managers were given the initial training in the use of toxicology

Journal Collection : The journal literature continues to be the primary means of
disseminating scientific information. The Library subscribed to approximately
700 periodicals during FY85, and, in addition, ordered 400 subscriptions for the
various laboratories. The Library continued to bind journals selectively or
replace them with microfilm to save space. The collection now includes 20,000
journal volumes and 1,750 microfilm reels. The Library, working with the EPA
Library, updated its computer-generated journal holdings list for FY85.

Book Collection : Continuing the development of the book collection, the Library
ordered 1,450 books in FY85, of which 40% were ordered for the Library and 60%
for the laboratories. The Library also ordered more than 300 technical reports.

Computer Catalog : FY85 was the third year of operation for the C.L. Systems
LIBS 100 computerized catalog and circulation system. This computer supports an
online catalog of the books in the Library and in the Labs and is searchable by
author, title, or subject using terminals in the Library or any terminal in the
labs or offices, thus making it much easier for Institutes scientists to find
out what books are in the Library. The system also speeds up the check-out pro-
cedure, produces overdue notices, and provides statistical reports for manage-
ment purposes. During FY85 the system was used to check-out 250 books per
month. An acquisitions software module was used to put all book-ordering


information on the computer and have purchase orders printed out. The LIBS 100
System was demonstrated to several library groups, including graduate students
from the UNC School of Library Science.

The Library continued using the automated cataloging system, OCLC, a com-
puterized union catalog of books held by more than 3,500 libraries nationwide.
The NIEHS Library has experienced a tremendous savings in time owing to the 95%
hit rate for new books which already have cataloging data on OCLC. Through an
interface, catalog records are transmitted from the OCLC computer in Ohio to the
LIBS 100 computer in the NIEHS Library where they are immediately integrated
into the public catalog.

Inter! ibrary Loan : The number of photocopy and loan requests increased by 22%
in FY85, the total being 19,500. For the third year in a row, more of the
requests were filled from the Library collection (58%) than from other libraries
through interl ibrary loan (42%). This reflects the ongoing improvement in the
NIEHS collection.

The OCLC computerized catalog also proved useful for verifying titles for
interl ibrary loan and for locating libraries from which to borrow books

Online LibraryNational Institute of Environmental Health ScienceAnnual report : National Institute of Environmental Health Sciences (Volume 1985) → online text (page 3 of 114)