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National Institutes of Health (U.S.). Biomedical E.

Annual report: National Institutes of Health. Division of Research Services. Biomedical Engineering and Instrumentation Branch (Volume 1989) online

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BEIB, DRS
BEIB, DRS
NIH
FDA



COOPERATING UNITS (il any)

National Center for Devices and Radiological Health, FDA



LAB/BRANCH

Biomedical Engineering and Instrumentation Branch



Mechanical Engineering



INSTITUTE AND LOCATION

DRS, National Institutes of Health, Bethesda, MP 20892



TOTAL MAN- YEARS:



0.5



PROFESSIONAL:



0.5



CHECK APPROPRIATE BOX(ES)

K (a) Human subjects
D (a1) Minors
D (a2) Interviews



D (b) Human tissues D (c) Neither



SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space provided.)

Mammography plays a vital part in the early detection of
breast cancer. Unfortunately, mammography units being used
today have never been analyzed from a systems point of view.
Multiparameter optimization studies of a mammography system
have been reported by Muntz et al (Med. Phys 12, 5, 1985) in
which the patient dose has been minimized, while maintaining^
satisfactory image quality. The most important new feature
of the design is the presence of an array of thin metal vanes
arranged in an arc about the x-ray source, between the breast
and the film. The vanes absorb scattered radiation and thus
improve the quality of the image. In order for the vanes not
to image on the film the grid must move in a precisely
controlled profile during the exposure.



PHS 6040 (Rev. 1/84)



GPO ai4-S1(



181



DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE

NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER

Z01 RS 10330-01 BEI



PERIOD COVERED

October 1, 1988 to September 30, 1989



TITLE OF PROJECT (BO characters or less. Title must tit on one line txtween the txjrders.)

Kinetics of Erythrocyte Sickling in Physiological Conditions



PRINCIPAL INVESTIGATOR (Ust other professional personnel tielow the Principal Investigator.) (Name, title, laboratory, and Institute attillaUon)



A. Eidsath

W. Eaton

J. Hofrichter



Staff Fellow, MES
Acting Chief. LCP
Senior Staff



BEIB, DRS
LCP, NIDDKD
LCP, NIDDKD



COOPERATING UNITS (H any)

Laboratory of Chemical Physics, NIDDKD



LAB/BRANCH

Biomedical Engineering and Instrumentation Branch



Mechanical Engineering



INSTITUTE AND LOCATION

DRS, National Institutes of Health, Bethesda, MD 20892



TOTAL MAN-YEARS:



0.3



PROFESSIONAL



0.3



CHECK APPROPRIATE BOX(ES)

D (a) Human subjects
D (a1) Minors
□ (a2) Interviews



(b) Human tissues D (c) Neither



SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space provided.)

We are using a flow cell in which the partial pressure of
oxygen can be varied rapidly in order to study sickling under
conditions that more resemble physiological conditions than
have been used in the past. Since there is a broad
distribution in the cellular hemoglobin concentration, many
cells need to be analyzed simultaneously. The change in
shape of the cells in the flow cell is observed under a
microscope. A video camera transmits the picture to a
computer, where the fraction of cells that have sickled can
be automatically determined using image analysis algorithms.



PHS 6040 (Rev. 1/84)



CPO 9l4-«lt



VETERINARY RESOURCES BRANCH
DIVISION OF RESEARCH SERVICES
NATIONAL INSTITUTES OF HEALTH

FY 1989 VRB ANNUAL REPORT
Dr. Stephen Potkay, Chief



VETERINARY RESOURCES BRANCH
DIVISION OF RESEARCH SERVICES
NATIONAL INSTITUTES OF HEALTH

FY 1989 VRB ANNUAL REPORT
Dr. Stephen Potkay, Chief



VRB Research Project (ZOl RS)



No.

00001-19

00051-09

00071-05
00073-05
00077-05
00078-04
00080-03
00081-03

00082-02
00083-02
00084-02
00085-01



Title



Animal Model Development

Reproduction in Mutant Sheep Used
for the Study of Hyperbilirubinemia

Development of Genetic Profiles for
Inbred Laboratory Rodents

Lipid Metabolism of the Macaca
fascicular is

Development of an Embryo Cryopreservation
Program in Laboratory Animals

Serum Cholesterol Values of the NIH
WHHL Rabbit

Effects of Progesterone on CEH in the
SLA Inbred Miniature Pig

Control of Luteal Function and Induction
of Ovulation and Conception in the
Anestrus Bitch

Acute Effects of Thromboxane Symthetase
Inhibition in Gravid Macaques

Mouse Strain Susceptibility to Bacillus
Piliformis

Development of Genetic Profiles for
Inbred Laboratory Rodents

Modification of the Breeding Cycle of
Sheep by Melatonin



Investigator


Page No


C. T. Hansen


1


L. D. Stuart


3


J. S. Crowell


6


D. Bai-nard


8


P. Schmidt


11


D. Barnard


15


K. J. Lipetz


18


P. K. Chakroborty


20


D. Jarrell


22


K. S. Waggle


24


J. S. Crowell


26-


L. D. Stuart


28



DEPARTMENT OF HEALTH AND HUMAN SERVICES • PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBEH

ZOl RS 00001-19 VR



PEHlOD COVERED

Occobcr 1, 1988 to September 30, 1989



TITLE OF PROJECT (00 cfmncmn Of iau. TiOt mutl tn on onm linm (wrwiMn :ht oonjmrt.)

AiiLmal Model Development



PRINCIPAL INVESTIGATOR (LM otrtf pnjt»»*ional (mnonrmi owow m« PnoofMl ln¥»$ugalof.j (Namt, UM. laoontofy. an<3 ntinui* »nilitUon)

PI: Carl T. Hansen Geneticist '" SAS , VRB, DRR



COOPERATING UNITS (» *ny)



LAS/BRANCH

Veterinary Resources Brancli



SECTION

Small Aninjal Section



INSTITUTE AND LOCATION

URS, NIil, Bethesda, Maryland 20892



TOTAL MAN- YEARS:

1.0



HROfHtSSlONAL:

i.O



CHECK A>»PROPRlATE BOX^ES)

D (a) Human subjects
D (ai) Minors
D (a2) Interviews



D (b) Human tissues lEl (c) Neither



SUMMARY Of WORK (Um JO/ioan} unnOucma ryp*. Do /km €*cmmd thm MfMtcm pfwuMd.)

The objective of this program is developing new models for biomedical research
utilizing ttie natural genetic variation found in sexually reproducing small re-
search animals. The emphasis has been with certain mutants which are known to
affect the functioning of the immune system, metabolic and neurological systems in
rats and mice. The strategy has been to establish these mutants on different
genetic backrounds as well as making different combinations of independantly ap-
pearing mutants. The result has been the formation of a unique resource of animal
models which is gradually finding increasing acceptance by the research community.



PHS 60*0 (R»» l/M)



DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER



ZOl RS 00051-09 VR



PERIOD COVERED

Octohjer 1, 1988 through September 'AO , i'JH'J



TITLE OF PROJECT ^80 cfiartctmn or Atu. Tim must tit oo onm lim C>mtw»an tfn oofXMn )

Reproduction m Mutant Sheep used for the Study of Hyperbilirubinemia



PRINCIPAL INVESTIGATOR (Lit ottytr pro/oaaional prionrml btcnt tf>* Pnnapl Intmaogmlor ) (Namt, BM, Imtxjrmtoiy, uxi mamutt tmiiaoon)

PI: L.D. Stuart Chief . UU, ACS, VRB, DRS



Others: D.E. Wildt



S.C. Kaiser
P.K. Chakraborty



Reproductive

Physiologist
Director
Head



NZP, Smithsonian Institution

Liver Diseases Pro:', DDN, NIAID
Research Division, Dept. of OB-
GYN, USUllS



COOPERATING UNITS (» any)

Digestive Diseases and Nutrition Program, National Institutes
of Arthritis, Metabolism and Digestive Diseases



LAB/BRANCH

Veterinary Resources Branch



SECTION

Animal Center Section



INSTITUTE AND LOCATION

DRS, NIH, Bethesda, Maryland 20892



TOTAL MAN-YEAflS;



PHOFESSiONAL:

. 1



. ]



CHECK APPROPRIATE BOX(ES)

D (a) Human subjects
D (al) Minors
D (a2) Interviews



D (b) Human tissues Q (c) Neither



SUMMARY OP V^RK <Us» ttandani unnducad lyp: Do not ancmad tfw tpaca pimKlad.)

A specific genetic strain of Corriedale sheep is used as an animal
model for the study of liver pathophysiology, specifically,
hyperbilirubinemia (Dubin- Johnson Syndrome). This project is
concerned with increasing the numbers of animals available for
research by the controlled breeding of individuals which
genetically transmit this character. This project is utilizing what
is considered to be the only existing Corriedale sheep homosygotic
for this trait. Efforts are being made to obtain both homozygous and
heterozygous offspring from these highly inbred individuals. Semen
collected artifically from the homozygotic rams was diluted in
various cryoprotective extenders and then freeze preserved. This
will ensure the long term availablity of male gametes for artifical
insemination. Overall this project allows prepetuation of this
specific gene pool and ensures availability of research animal for
future investigations of Dubin- Johnson Syndrome and related metabolic
disorders .



PHS 60*0 (Rev 1/84)



0i»O tl 4-»>



DEPARTMENT OF HEALTH AND HUMAN SERVICES • PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER



ZOl RS-00071-05 VR



PERIOD COVERED

October 1, 1988 to September 30, 1989



TfTLE OF PROJECT (60 chtrtcmrs or Im Tirie muit In on one kne bttwtn ttt* iMXZtmrt )

Development of Genetic Profiles for Inbred Laboratory Rodents



PRINCIPAL INVESTIGATOR (USI oltie: prvl9isior>*i penonnti t)0low irm Prmcf)*! Invtsuottcx j (Namt. Out. Imtxytory. mnd tiMOtutt tfl^ifbon)

J.S. Crowell, Geneticist Comparative Pathology Section, VRB, DRS

S.L. Finley, Biochemist Comparative Pathology Section, VRB, DRS



COOPERATING UNITS frf ^ny;



Small Animal Section, VRB, DRS



LAB/BRANCH

Veterinary Resources Branch



SECTION

Comparative Pathology Section



INSTITUTE AND LOCATION

Division of Research Services, Bethesda, Maryland 20892



TOTAL MAN- YEARS:

0.5



PROFESSIONAL:

0.4



0.1



CHECK APPROPRIATE BOX(ES)

D (a) Human subjects D (b) Human tissues (c) Neither

D (a1) Minors
D (a2) Interviews



SUMMARY OF WORK (Uie tfndtrti unreducva type. Do not »fC9»cl the spmct prnvkfad.)

This project is designed to identify and locate .on the chromosomes of
inbred rodents inherited characteristics which can be used in a wide
range of biomedical research and to further the ability of the Genetic
Monitoring Unit to perform its basic laission. The major .areas of
interest are: 1) characterization of the genetic traits by b iochemical
and immunological techniques ; 2) chromosome mapping by standard genetic
analysis; and 3) application of the genetic characteristics to explore
new animal models of pathogenesis.



PHS 6O40 (fW. 1/W)



»ro »\*^\»



PROJECT NUMBEfl

DEPARTMENT OF HEALTH ANOHUMAN SERVICES - PUBLIC HEALTH SERVICE



NOTICE OF INTRAMURAL RESEARCH PROJECT



ZOl RS 00073-05 VR



PERIOD COVERED

October 1, 1988 to September 30, 1989



TITLE OF PROJECT (BO cnartccri or mat. Via* mutt In oo on* Imm CMlwmn ity» Ootvn.)

Lipid Metabolism of the Maeaca fascicularis



PRINCIPAL INVESTIGATOR (Ust oitnr ptvtmtMJotl pmnonrmi Ottow Iht Pnnapal Irnaatignof j (Namt, av». Itxxmloiy, tn) msmum ttlUiauon)

PI: Dennis Barnard Biologist SAS, VRB, DRS

Joseph Knapka Physiologist SAS, VRB, DRS



COOPEHATINQ UNITS (t any)



LAa/BHANCH

Veterinary Resources Branch



SECTION

Small Animal Section



INSTfTUTE AND L0CATK3N



DRS. NIH. Bethesda. Maryland 20892



TOTAL MAN-YEAftS:

0.6



PHOFESStONAL:

0.1



OTHER:

0.5



CHECK APPROPRIATE BOX<ES)

D (a) Human subjects D (b) Human tissues @ (c) Neither

D (al) Minors
D (a2) Interviews



SUMMARY OF WORK (U»» jra/Kian} unnauctd ryp*. Do no( txcmd (Tm ifmct ptmiOta.)

The study will examine the metabolism of exogenous fatty acids by Maeaca fascicularis .
Trans fatty acids which cannot be synthesized by eukaryotes will be used as the
exogenous fatty acid mari<er. These fatty acids are geometrical isomers of cis fatty
acids which can be synthesized by eukaryotes. The trans fatty acids are catabolized and
removed from the body shortly after the fatty acids are removed from the diet. Twelve
male M. fascicularis monkey were used in the study. Six were fed the control diet, and
the others received the experimental diet. The RBC membrane of monkeys fed the
control diet contained .5% trans octadecanoate isomers of the fatty acids. Examination
of the fecal fatty acids from these monkeys showed that biohydrogenation does occur in
their gut producing trans fatty acids which appear to be incorporated into the RBC
membrane. Within 6 weeks after initiating the study the RBC membranes of monkeys
fed the experimental diet contained 10.8% trans octadecanoate isomers of the total fatty
acids. DPH steady state fluorescence polarization analysis of the erythrocyte membrane
fluidity showed no change in membrane fluidity between the monkeys fed the two diets.
However, insulin binding activity was altered in the monkeys fed the diet containing
trans fatty acids.



PmS 6040 (R»v 1/64)



DEPARTMENT OF HEALTH AND HUMAN SERVICES • PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER

ZOl RS 00077-05 VR '



PERIOD COVERED

October 1, 1988 to September 30, 1989



TITLE OF PROJECT (80 chfcmn or /•«. We must W on on* lin« between the boroersj

Development of an Embryo Cry op re se rva t ion Program in Laboratory Animal



PRINCIPAL INVESTIGATOR (Ust other proteaaional personnel tietow ttie PnrKipel Investigator ) (Name, tme, laboratory, and inamute artiliitior)



PI: Patricia M. Schmidt
Carl T. Hansen
David E. Wildt
William F. Rail



I'hysiologis t SAS,VRB,DRS
Geneticist SAS,VRB,DRS
GuQSt Researcher VRB,DRS
Guest Researcher VRU,DRS



COOPEHATINQ UNITS (H any)



LAB/BRANCH

Veterinary Resources Branch



SECTION

Small Animal Section



INSTITUTE AND LOCATION

DRS ,NIH, Behesda, Maryland 20892



TOTAL MAN- YEARS;

3.



PROFESSIONAL;

2 .



1 .



CHECK APPROPRIATE BOX(ES)

D (a) Human subjects
D (a1) Minors
D (a2) Interviews



D (b) Human tissues D (c) Neither



SUMMARY OF WORK (Use stanaam unreduced type. Do not tjrcMd the space provided.)

The program objective is to facilitate the management o
Animal Genetic Resource (NIHAGR) through the developmen
zation of techniques such as collection, culture, freez
fer of embryos and gametes for cryobanking genetic mate
proving reproductive potential. The NIHAGR maintains a
critical s pe c ie s ;.iand , within species, a vast number of
genotypes used in biomedical research. Embryo preserva
cryop rote ct ant in the freezing medium which allows suff
ration to protect the blastomeres during freezing, Fol
and dilution of the cryop rote ct an t , embryos are culture
vitro development. Transplantation of embryos into rec
monitors in vl t ro fertilization and ova freezing are be
techniques to salvage limited genetic material from sin
strains with poor i_n vitro fertilization rates. Banked
maintained in a frozen state until needed for rederivat
focus of laboratory efforts is the study and optimizati
banking technology in mice and rabbits and more recentl
major research finding is that embryo freezability is c
influenced markedly by mouse genotype. Such responses
amined in over 56 genotypes, most of which display geno
survival rates to standardize embryo f ree ze^^ thawing pro
ciliary projects are oriented toward the comparative as
proving long-term embryo storage with particular emphas
of cryopro t e c t ant s and enhancing methods for embryo fre
dilution and transfer. Efforts in the rabbit focus on
collection procedures and preservation of embryos.



f the NIH
t and utili-
ing and trans-
rial and im-

number of
inva luab le
tion uses a
icient dehyd'-
lowing thawing
d to assess in
ipient females
ing examined as
gle females or

embryos are
ion , A primary
on of cryo-
y, in rats, A
on f ounde d and
have been ex-
type-^snecific
cedure s . An-
pects of im'^
is on the study
e z ing , thawing ,
improvements in



PmS 6040 (Rev 1/84)



GPO •< 4-*<*



DEPARTMENT OF HEALTH AND HUMAN SERVICES • PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER



ZOl RS 00078-04 VR



PERIOD COVERED

October 1, 1988 to September 30, 1989



TITLE OF PROJECT (80 ct-^nciun or l»ta. Tim mutt AT on on* An* o*iw*«n tn» txxotn.)

Serum Cholesterol Values of the NIH WHHL Rabbit



PRINCIPAL INVESTIGATOR (Ut ottm (tnittitonal ptrtonntl Cmtow Ih* PnneifM InvtogmlOf.) (Nvrm, tnh, lattontoty. uxt mtmuf artUmoot))



PI: Dennis Barnard
Cheri Reid-Quinn
William Watson
Joseph Knapka



Biologist
Veterinarian
Veterinarian
Physiologist



SAS, VRB, DRS

SAS, VRB, DRS

SAS, VRB, DRS

SAS, VRB, DRS



COOPERATING UNITS (» try}



LAS/BRANCH

Veterinary Resources Branch



SECTION

Small Animal Section



INSTITUTE AND LOCATION

DRS, NIH, Bethesda, Maryland 20892



TOTAL MAN-YEAAS;



1.0



PHOHiSSIONAL:



0.5



OThEH:



0.5



CHECK APPFIOPRIATE BOX(ES)

D (a) Human subjects
D (al) Minors
D (a2) Interviews



D (b) Human tissues Q (c) Neither



SUMMARY Of WORK (U— antmMAf unnOucMl lyp*. Oo not axOMd m* tpmoa prmiOma.)

The Veterinary Resources Branch, Division of Research Services
established a Wacanbe Hyperlip idemic Rabbit (WHHL) breeding colony
to be used as a resource for investigators requiring the use of this
animal model. The colony is being characterized for serum tri-
glyceride levels. Blood is being collected from rabbits at the
following ages: six weeks, three months, seven months, and one year
Total serum cholesterol values ranged from 310 to 1251 mg/dl with a
mean of 828 mg/dl. The low density lipoprotein (LDL) cholesterol
values ranges from 1185 mg/dl with a mean of 630 mg/dl. Thus 80%
of the total cholesterol was composed of LDL cholesterol. There
was a substantial decrease from 885 to 576 mg/dl in serum total
cholesterol between the ages of eight weeks and one year. The most
significant ' decrease occurred between the ages of 15 to 25 weeks.
There was no difference in total cholesterol concentrations due to
sex. The. serum triglyceride values ranged from 107 to 959 mg/dl_
with a mean of 394 mg/dl within one year of age. The serum tri-
glyceride concentration decreased to 349 mg/dl within one year of
age. The serum triglyceride concentration was influenced by the
sex of the rabbit. The mean male and female serum triglyceride
concentrations were 5 10 mg/dl and 309 mg/dl respectively.



PHS 60«0 (R«y 1/841



DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PHOjECT NUMBE3



ZOl RS 00080-03 VR



PERIOD COVERED

October 1, 1988 to September 30, 1989



TITLE OF PROJECT (80 cnmncnn Of *M. T/rt* mull tn on on* lirm 0«iw*«fi tna tXHVn.)

Effects of Progesterone on CEH in the SLA Inbred Miniature Pig



PRINCIPAL INVESTIGATOR (Utl ottttf pfot»asionaJ pmrtonrml tMtow tt» Prmapttl Inmngator ) (Nam; aOa, Imtxmtory. trxl maatua t/rumoon)

Pi: K.J. Lipetz Director of Lab. Montgomery infertiiity

Inst .



Others



L.D,

N. L,



Stuart
Garnett



Chief

Vet. Med. Officer



UU, ACS, VlUi, DiiS
AKP , Dim



COOPERATINQ UNITS (» any!



lAe^RANCH

Veterinary Recources Branch



SECTION

Animal Center Section



INSTTTUTE AND LOCATION

DRS, NIH, Bethesda, MD 20892



TOTAL MAN-YEAflS:

.05



PROFESSKDNAL;

.025



025



CHECK APPROPRIATE 90X<ES)

D (a) Human subjects
D (al) Minors
D (a2) Interviews



D (b) Human tissues E (c) Neither



SUMMARY Of WORK (Um stanaarxl unntducad lyp*. Do not axomtd <fm apmoa prmiOad.)

The SLA inbred miniature pig herd, bred and maintained by the
Ungulate Unit for the Immunology Branch, NCI typically produces a
small litter and exhibits a variety of reproductive problems not
found in the standard-sized pig. A uterine condition, cystic
endometrial hyperplasia (CEH), exists in the herd. Sows that are
not bred until after one year of age have a high incidence of CEM
and are incapable of reproduction. Regression or reduction of the
incidence of CEH would improve greatly the reproductive performance
of the herd. Previous studies have shown the SLA inbred miniature
pig has a serum progesterone level considerably lower than the
standard-sized pig. The effects of long term administration of
progesterone of CEH will be studied.



PmS S040 (Rev 1/84)



S^O »li-*\*



DEPARTMENT OF HEALTH AND HUrtAN SERVICES • PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER

ZOl RS 00081-03 VR



PERIOD COVERED

October 1. 1988 to September 30, 1989



TITLE OF PROJECT (80 cfMnctmn ot <*u. Tmt muil tn on on* lin* otrwm^n tti» txxOfs.)

Control of Luteal Function and Induction of Ovulation and Conception in the Anestrus Bitch.



PRINCIPAL INVESTIGATOR (List othf pmltsiontt pmrsonnmi Ckhow m* Prmapal Invmstigmiof ) (Namt. OtM, lUMfmlofy, tnO insmutt mttilmuon)

PI. P. K. Chakroborty Head, Research Division USUHS

Obstetrics & Gynecology



Others:



R. L. Killens
J. L. Brown



Chief, Carnivore Unit
Research Associate
Obstetrics & Gynecology



ACS/VRB/DRS
USUHS



COOPEHATINQ UNITS (M tny)

Carnivore Unit, ACS, VRB, DRS; Research Division, Department of Obstetrics and
Gynecology, USUHS.



oa/B RANCH

Veterinarv Research Branch



Animal Cpnter Spr^tinn



INSTITUTE AND LOCATKDN

DRS, NTH, RpthP-^rlfl, MppvlanrI 9nSQ9



TOTAL MAN- YEARS:

.6



professional:

iL_



CHECK APPROPRIATE BOX(ES)

D (a) Human subjects
D (al) Minors
D (a2) Interviews



D (b) Human tissues E) (c) Neither



SUMMARY OF WORK (Usm ttanaarO unrtductcl fyfm. Do ml axcwd in* $pacm fmmami.)

This project is designed to study the effect of two treatment regimens using hormone
stimulants to induce ovulation and conception in bitches. The major areas oflnterest
are: 1) the induction of regression of the funct ional corpora lutea by hormone
administrative ; and 2) the induction of follicular development and ovulation followed by
breeding bitches pretreated with hormone to regress corpora lutea.



PmS 6040 (Rev 1/»4|



amo ti *-*it



PROJECT NUMBER
DEPARTMENT OF HEALTH AND HUMAN SERVICES ■ PUBLIC HEALTH SERVICE



NOTICE OF INTRAMURAL RESEARCH PROJECT



ZOl RS 00082-02 VR



PERIOD COVERED

October 1, 1989 through September 30, 1990



TITLE Of PROJECT (80 cfuuTcntn or J»m. Titf must tn on on» iin» o»tw»*n rr>» t>ora»f3.)

Acute Effects of Thromboxane Synthetase Inhibition in Gravid Macaques

PRINCIPAL INVESTIGATOR (Uat otr>»f prottMXtl ptrtonrml OvHnv in« Pnnapal ln»mtii^ttof.J (N*m». UIM. hcxxaioiy, tnd mtmutm tltiinuotij

PI: D. Jarrell Chief PU, ACS, VRB, DRS

Others: F. Judge Acting Chief ACS, VRB, DRS

J- Keith Assoc. Prof. VMRCVM (VA-MD Reg.

Col. Vet. Med.)



COOPEHATINQ UNITS l» any)

VA-MD Regional College of Veterinary Medicine



UAa/BAANCH

Veterinary Resources Branch



SECTION

Animal Center Section



INSTiruTt AND LOCAnON



DRS, NIH, Bethesda. Maryland 9nS9';>



TOTAL MAN-YEARS: - J PWOFESStONAL;

0.050



0.025



0.020



CHECK APPROPRIATE BOX<ES)

D (a) Human subjects D (b) Human tissues E (c) Neither
D (al) Minors
D (a2) Interviews



SUMMARY OF WORK (Um irmnatnl unnducad lyp». On nol •jtcvm' tfw tfMCm prmidaa.)

Preeclampsia is a hypertensive disease of late pregnancy and is a major cause of
maternal and fetal mortality and morbidity. Five to ten percent of all pregnancies and
up to 20 percent of primagravidas are affected yearly in the United States. The only
curative treatment for this syndrome is early delivery, resulting in many neonatal
complications due to prematurity.

Recently several laboratories have documented low levels of prostacyclin (PG12) and/or
elevated levels of thromboxane A2(TxA2) 1-5. Similar results have been seen in this
disease in an ovine model of preeclampsia, and beneficial, effects of thromboxane
synthetase inhibitors have been reported in the ovine model. However, the effects of
thromboxine synthetase inhibitors have not been studied in gravid primates.

The purpose of this study is to determine the effects of CGS 12970, 3-methyl-2
(3-pyrodyl)-l-idoleoctanoic acid, a thromboxane synthetase inhibitor, in gravid nonhuman
primates (rhesus).



PhS 6640 (Ro» 1/tH) ii<>o ti4-»n



DEPARTMENT OF HEALTH AND HLIMAN SERVICES • PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER



ZOl RS 00083-02 VR



PERIOD COVERED

October 1,1988 to September 30, 1989



TITLE Of PROJECT (80 chartcmrs or l»ss Ttttt must in on ont kne barwen (fie bomera.)

Mouse Strain Susceptibility to Bacillus piliformis.



PRINCIPAL INVESTIGATOR (UsI Other proltiSKjntJ pttrtonntl tflow me Principal inrntiQalor.) (Nuna, oUe, latMfalory, and mwjle attuianon)

PI: K.S. Waggie Chief, Microbiology Unit CPS.VRB.DRS
C.T.Hansen Geneticist SAS.VRB.DRS



COOPERATING UNITS (It any)



LAB/BRANCH

Veterinary Resources Branch



SECTION

Comparative Pathology Section and Small Animal Section


1 2 3 4 5 6 8

Online LibraryNational Institutes of Health (U.S.). Biomedical EAnnual report: National Institutes of Health. Division of Research Services. Biomedical Engineering and Instrumentation Branch (Volume 1989) → online text (page 8 of 9)