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National Institutes of Health (U.S.). Biomedical E.

Annual report: National Institutes of Health. Division of Research Services. Biomedical Engineering and Instrumentation Branch (Volume 1989) online

. (page 9 of 9)
Online LibraryNational Institutes of Health (U.S.). Biomedical EAnnual report: National Institutes of Health. Division of Research Services. Biomedical Engineering and Instrumentation Branch (Volume 1989) → online text (page 9 of 9)
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INSTITUTE AND LOCATION

DRS,N1H Bethesda, Maryland 20892



TOTAL MAN- YEARS

.06



PROFESSIONAL:
.02



OTHER
OA



CHECK APPROPRIATE BOX(ES)

D (a) Human subjects D (b) Human tissues ]Q (c) Neither

D (a1) Minors
D (a2) Interviews



SUMMARY OF WORK (Use standard unraduced type. Do not a*c«ed the space provided )

The objective of this project was to find a mouse strain that is susceptible to B.
piliformis infection via the oral (natural) route. A susceptible strain would alZ



in pathogenesis studies and might act as sentinel animals to detect naturally
occurring infections in rodent colonies.

Mice with various immunodeficiencies were orally inoculated with B. piliformis
spores. Mice were killed 5 days post-inoculation and examined for gross lesions.
Tissues were also collected for histopathology. Mouse strains utilized were as
follows: CBA/N, P/N, C3H/HeJ , C3H/HeN (C3H) , C3H-nu, C3H-bg, C3H-xid, C3H-bg,nu;
C3H-bg,xid; C3H-nu,xid.

No significant gross lesions were present in any of the inoculated mice. Cecoco-
litis was microscopically evident in C3H-bg,nu mice, however, no B. piliformi s -
like bacteria were observed in silver stained sections. Further studies need to
be done to determine if C3H-bg,nu mice are susceptible to B. piliformis infection
and, if so, if they would be a suitable sentinel animal.



PHS 60*0 (R«v 1/W)



DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT



PROJECT NUMBER



ZOl RS 0008A-Q2 VR



PERIOD COVERED

October 1, 1988 to September 30, 1989



TITLE OF PROJECT (BO characters or less Title must lit on one line between the borders )

Development of Genetic Profiles for Inbred Laboratory Rodents



PRINCIPAL INVESTIGATOR fusi other professional personnel txilow the Principal Investigator.) (Name, title, latxiratory. and institute atfiliation)



J.S. Crowell, Geneticist
S.L. Finley, Biochemist



Comparative Pathology Section, VRB , DRS
Comparative Pathology Section, VRB, DRS



COOPERATING UNITS (il any)



Small Animal Section, VRB, DRS



LAB/BRANCH

Veterinary Resources Branch


SECTION

Comparative Pathology Section


INSTITUTE AND LOCATION

Division of Research Services, Bethesda,


Maryland 20892


TOTAL MAN-YEARS
0.5


PROFESSIONAL:
0.4


OTHER

0.1



CHECK APPROPRIATE BOX(ES)

D (a) Human subjects
D (a1) Minors
D (a2) Interviews



D (b) Human tissues (c) Neither



SUMMARY OF WORK (Use standard unreduced type Do not exceed the space provided.)

This project is designed to identify and locate on the chromosomes of
inbred rodents inherited characteristics which can be used in a wide
range of biomedical research and to further the ability of the Genetic
Monitoring Unit to perform its basic mission. The major areas of
interest are: 1) characterization of the genetic traits by biochemical
and immunological techniques ; 2) chromosome mapping by standard genetic
analysis; and 3) application of the genetic characteristics to explore
new animal models of pathogenesis .



PhS 6040 (Rew 1/84)



a»o si4-«it



; PROJECT NUMBEfl
DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE



NOTICE OF INTRAMURAL RESEARCH PROJECT



ZOi RS 00085-01 VR



PERIOD COVERED

October i, 1988 through September 30, 1989



TITLE OF PROJECT (80 ct\trmcmrs or fia. TiOt must ttt on orm lina Ottwan m« txyxJtn.j

Modification of the Breeding Cycle of Sheep by Melatonin

PRINCIPAL INVESTIGATOR (Lat off>»r pmttsnonal pmnonrmi bmtow tht PnnaptU Invmaogtiof ) (Naw», tttM, labortrofy. uxt mamun »/tilmaoo)

PI: L.D. Stuart Chief UU , ACS, VRB, UldS

Others: D.M. Jarreli Chief PU , ACS, VRB, DRS

L. Tamarkin Assistant Prof. University of Maryland

M.A.A. Namboodiri Assistant Prof. Georgetown iThiversity

J.E. Pierce Guest Researcher NHLBi, NIH



COOPERATING UNITS (H any)



LAS/BRANCH

Veterinary Resources Branch



SECTION

Animal Center Section



INSTTTUTE AND LOCATION

DRS, NIH, Bethesda, Maryland 20892



TOTAL MAN- YEARS:

.6



PROFESSIONAL;

. 1



CHECK APPROPRIATE 80X<ES)

D (a) Human subjects D (b) Human tissues El (c) Neither

D (al) Minors
D (a2) Interviews



SUMMARY OF WORK (Urn sfnaan} unnducaU ryp: Do not txotmcl tfw tpacm pnmOmi.)

This project is designed to control the breeding cycle in sheep
and to breed ewes out of season. Data exists that indicated
the rhythmic secretion of the pineal hormone, melatonin, regulates
seasonal breeding in a variety of mammals, including sheep. Sheep
usually breed in the fall when elevated levels of ciruclation
melatonin are longer (mimicking the longer night). During the
spring when levels of melatonin are shorted, sheep enter a period of
anestrus. Elevated levels of melatonin will be maintained by dally
feeding of melatonin.



PMS 6040 (R»v 1/94)



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W^H L,5ra/y. eliding W



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NMH

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Researeh.
Amazing Help.



http://nihlibrary.nih.gov



10 Center Drive

Bethesda, MD 20892-1150

301-496-1080





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Online LibraryNational Institutes of Health (U.S.). Biomedical EAnnual report: National Institutes of Health. Division of Research Services. Biomedical Engineering and Instrumentation Branch (Volume 1989) → online text (page 9 of 9)