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Condensations after Influenza.) Victor Schilling. Berl. klin. Wchnschr., 1920, 57,
X-ray pictures of the thoracic cavity of persons who have recovered from influenza show

certain extended areas of shadow with dense centers which are believed to be pus foci in the

septa, interstitial tissue or the bronchi. — B. C.

$16i. Ueber Enzephalomyelitis bei Grippe. (Encephalomyelitis in Influenza.) J. E. Katsbr-

Pbtbrson. Berl. klin. Wchnschr., 1920, 57, 632-^34.

Are the numerous forms of encephalitis, many described under different names, to be con-
sidered as a single disease? Is there a close relation between encephalitic infections and the
influenza epidemic? These questions are discussed in the li^t of admittedly meagre infor-
mation so far at hand. Bacteriologically, there are 2 possibiBties; (1) that the influenza and
encephalitis virus are identical, analogous to certain manifestations of S3rphilis; or (2) that
it is a matter of a mixed infection whereby the influenza virus encourages the secondary
infection by reducing the resistance of the organism or by activating the encephalitis virus.
— B. C.

2166. Ueber chronische Grippe. (Chronic Influenza.) Wilhblm Hildbbrandt. Mdnchen.

med. Wchnschr., 1920, $7. 1008-1009.

The recent influenza jpandemic was preceded by an extensive endemic incidence of influ-
enza in 1915 and 1916. Pfeiffer's influenza bacillus seems to be the etiologic agent. The
various clinical features are discussed in their relation to tuberculosis. The differentiation
of tuberculosis and influenza is one of the most difficult problems in the differential diagnosis
for pulmonary tuberculosis. — B. C.

£166. Suversaninjektionen (Menthol-Euk<dyptol-Berliner) bei Grippe. (Injection of Supersan
(Berliner's Menthol-Eucalyptol) in Influenza.) Arnold Fuchs. MQnchen. med. Wchn-
schr, 1920, 67, lOia-1019.
Intramuscular injection (1 to 2 cc.) of a mixture of menthol and eucal3rptol seems to have

a favorable influence in the course of respiratory diseases like influenza, bronchitis, etc. —

B. C.

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B167. Die chemotherapetUische Behandlung der Grippe. (The Chemotherapeutic Treatment of
Influenza.) Alfred Albxander. Deutsche med. Wchnschr., Berl. & Leipz., 1920,

Influenza, especially the t3rpe with a mild onset, is considered dangerous, and prompt,
vigorous treatment should be mstituted to prevent complications. Optochin and eucupin
are very valuable agents against streptococci and diplococci, where these invaders complicate
the situation. Intramuscular injections of vuzin in the graver septic and encephalitio com-
plications seem to have remarkable curative effect. — B. C.

il68. Die Rolle dies Vuzina bei der Grippe-bekdrnpfunq. (The Rdle of Vuzin in the Influenza
Campaign.) Paul Rosbnstein. Berl. klin. Wchnschr., 1920, 57, 463-467.
Vuzin, one of Morgenroth's quinine derivatives, is an excellent material for the preven-
tion and combating of all septic conditions following influenza, especially early empvema.
Even in general sepsis^ it appears that intramuscular injections of vuzin plus argato?^l (which
stimulates leucocytosis) are effective in causing a recession of the s3anptoms. — ^B. C,


BW9. Studies in Epidemic (Lethargic) Encephalitis, Cultural Studies, L. Loewb Ain) I.

Strauss. J. Infect. Dis., Chicago, 1920, 27, 250-269.

By using the ascitic-fluid tissue medium of Noguchi the authors succeeded in cultivat-
ing a minute globoid organism which they regard as the parasite causing encephalitis lethar-
gica. An essential to success in the cultivation of this parasite is the use of sterile bile-free
ascitic fluid of high specific gravity (preferably from decompensated cardiac cases). Pieces
of sterile rabbit's kidney were added to the fluid, and the medium after inoculation covered
with a layer of sterile petrolatum, which obviates the use of a Novy jar to obtain the proper
degree of anaerobiosis.

Growths of the minute globoid organism were obtained from the brain, nasopharyngeal
mucous membrane, spinal fluid and blood — directly from some of the tissues and abo from tneir
Berkefeld filtrates. The same organism was recovered from the brain and phar^rngeal mucous
membranes of rabbits inoculated with material from human cases of encephalitis. The virus
in the cultures passed through Berkefeld filters.

The cultures from the tissues and fluids were infectious for rabbits, producing encephali-
tis in rabbits after intraspinal inoculation. The organism was recovered from rabbits thus
inoculated. Positive animal inoculations were obtamed from the eleventh subculture of the

Photographs are reproduced showins the morphology of the organism. The morpholojgy,
staining and cultural reactions are described in detail, wtih a method of isolating the organism
from colonies in semisolid medium.~S. B-J.

$170, Lethargic Encephalitis. A Report of Two CaseSj with the Isolation of a Streptococcus

from the Blood of One Case. Jacob Meyer. J. Nerv. & Ment. Dis., N. Y., 1920, 52,


This article reports the isolation from the blood of a hemolytic streptococcus with a
tendency to produce green on blood agar. It is not bile soluble, does not ferment inulin nor
mannite. ferments salicin and lactose and is not pathogenic when injected intravenously
into rabbits and guinea pigs. The organism did not grow aerobically in the first generation
but did so in the second generation.

The author also reviews the literature concerning the causation of lethargic encephalitis.
— F. W. H.

B17i. Ueber sporadische und epidemische Encephalitis — sog. Encephalitis lethargica — 6ei Kin'
dem. (Sporadic and Epidemic Encephalitis Lethargica in Children.) E. Wibland.
Schweiz. med. Wchnschr., 1920, No. 28, 681-590.
A review and discussion of the recent literature on encephalitic lethargica. Particular

attention is given to a possible relation between influenza ana encephalitis. — G. H. S.


(See also Numbers 19U, »10S, BBOS, $246, $$47, $$48, $$49, $$80, $$81, $$8$, $$83, $$84, 2B8S,
$$86, $$87, $$88, $$89, $80$, $$16, $319)

$17$. Twenty-four Years Experience with the SubctUaneous Tuberculin Test. Lawrason
Brown and Fred H. Hbise. Am. Rev. Tuberc, Bait., 1920, 4, 254-261.
During twenty-four years 324 patients received the subcutaneous tuberculin test, it being
given during the later years only to those patients without a parenchymatous X-ray pulmon-
ary lesion. Forty-two patients failed to react to a second dose of 0.01 cc. O.T. Such patients
can be safely returned home and to work. In no instance did the tuberculin produce a lasting
untoward result, and in only two instances did tubercle bacilli appear in the sputum for the
first time immeaiately after the test. Of seventy-five patients with a history of hemopt3r8i8,
over 90 per cent reacted to the tuberculin test. About 90 per cent of 144 patients with

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dry pleurisy and 90 per cent of 10 patients with wet pleurisy reacted positively . Of 41 patients
stuaied by X-ray onljr 3 showed a positive increase of shadows. Of 268 patients only 48 (18
per cent) showed an increase in riles during the reaction and 21 (8 per cent) a decrease.
''The subcutaneous tuberculin test when positive proves tuberculosis infection, but when
accompanied by definite clinical changes, or more surely if by increase of X-ray changes
(focal reaction) indicates that the lesion is more accessible to circulatory changes and pre-
sumably less firmly cicatrized (healed)." — ^T. G. H.

217S, Ueber Tvherkulinbehandlung mit beaonderer BerUckaichtigung der Intrakutanbehandlung.

(TttberciUin Therapy with Particular Reference to the IrUractUarhecms Method.) H. Sahu.

Schweiz. med. Wochschr., 1920, No. 27, 667-^567.

The technic of injection, methods of regulating dosage, and results secured, in the thera-
peutic use of tuberculin by intracutaneous infection are presented. This method of appli-
cation is considered superior to subcutaneous mjection. — G. H. S.

2174. The Influence of Creosote, Ouatacol and Related Substances on the Tubercle Bacillus and
on Experimental Tuberculosis. Studies on the Biochemistry and Chemotherapy of Tuber^
culosis XIX. L. M. DbWitt, B. Sutenaga and H. G. Wells. J. Infect. Dis., Chicago,
1920, 27, 116-135.

A study of the effect of creosote and related compounds upon the tubercle bacillus showed
that: "Virulent human tubercle bacilli are inhibited from growth (bacteriostatic action) on
artificial mediums containing a concentration of 0.01 per cent each of resorcin, thymol,
paracresol, orthocresol and metacresol. 0.05 per cent is the lowest concentration which
completely inhibited in the case of creosol and pyrocatechin. Guaiacol, creosote, hydroqui-
none and guaiacol cacodylate required a concentration of 0.1 per cent to inhibit growth com-
pletely. Sodiiun guaiacolate inhibited completely at 1.7 per cent and partiall)r at 0.8 per
cent. Thiocol did not inhibit in 1 per cent concentration and styracol did not inhibit in 10
per cent susi)ension.

Bactericidal tests, with exposure of cltmips of tubercle bacilli to solutions of these com-
pounds, and also b3r tne treatment of the bacilli in very thin layers on garnets, showed that
creosote and its derivatives have a relatively low bactericidal power for the tubercle bacillus.

One hundred and six guinea pigs were treated with large doses of these compounds over
a long period during various phases of infection with tubercufosis. No beneficial effect upon
the course of the experimental disease was apparent.

It is concluded that creosote and guaiacol do not have a specific action on tuberculous
infection. — S. B-J.

2175. Ueber intrauterine Tuberkuloseinfektion. (Intrauterine Infection with B. tuberculosis.)
M. Dubois. Schweiz. med. Wchnschr., 1920, No. 35, 772-776.

An extended analysis of the literature on intrauterine infection with B. tuberculosis is
followed by a case report. In the case in question both the mother and child came to autopsy
and a miliary tuberculosis was found in both. — G. H. S.

2176. Zur didtetischen Behandlung der Tuberkulose. (Dietetic Management in Tuberculosis.)
W. Stoeltzner. Mtinchen. med. Wchnschr., 1920, 67, 981-982. ^
Dietetic management in tuberculosis has always had for its principal aim the production

of an increase in weight regardless of other possible factors in the quality of the foods pre-
scribed. Based upon the older researches of Thomas and of Weigert, it is concluded that an
excess of carbohydrate in the diet is detrimental to the maintenance of a strong resistance to
tuberculosis. Experiments on tuberculous children in which diets high and low in purines
were fed gave no conclusive results. The author believes that a hi^h purine diet has a favor-
able effect but his experimental results are not decisive on this point. — B. C.

2177. Ueber die Pneumothoraxbehandlung der kindlichen Lungentuberkulose. (Pneumothorax
in the Treatment of Juvenile Pulmonary Tuberculosis.) Helens Euasbbrg. Deutsche
med. Wchnschr., 1920, 46, 961-964.

Production of prolonged artificial pneumothorax in juvenile pulmonary tuberculosis is
considered an important forward step m treatment. That such treatment prolongs life by
several years is now certain, but whether it will also lead to permanent cure is yet to be
demonstrated. — B. C.

2178. Zur Frage der offenen Lungentuberkulose im S&uglingsalter. (Open Pulmonary Tubercu^
culosis in Nurslings.) Klots. Mtinchen. med. Wclmschr., 1920, 67, 964.

In nurslings, pulmonary tuberculosis is to be considered open, i.e., in the contagious
state, even in the absence of bacilli in the sputum. Such an asstmiption, if occasionally
false, is however justified by the possible serious consequences due to the opposite point of
view.— B. C.

2179. Ueber die Einwirkungder Kriegsverh&ltnisse auf die Tuberkulosehdufigkeit unter den
MUnchener Kindem. (jThe Effect of War Conditions upon the Prevalence of Tuberculosis in
Children of Munich.) Josef Bartschmid. Mtinchen. med. Wchnschr., 1920, 67, 957-

Children became tuberculous (as indicated by the Pirquet test) earlier in life during the
war than during pre-war years. The tuberculosis death rate tendency, however, was not
very markedly changed. — ^B. C.

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2180, Zur Kasuisctik traumattaher Tuberkrdosen. (A Case oj Traumatic TuberculoM,) H.

Lau. Deutsche med. Wchnschr., Berl. & Leipz., 1920; 46. 999.

A case is described in which minor injui^ to the testis produced a locus of reduced resist*
ance followed three years later by tuberculosis of the organ. — B. C.

B181 . Eine metaluetisch-tuberkuldse Mischinfektton. {MetcUuetiC'Tvberculaus Mixed Infection. )
Kabl Zbhner. Schweiz. med. Wchnschr., 1920, No. 30, 651-653.
Report of a case.— G. H. S.

B08B, The Influence of Smallpox and Vaccination on Pulmonary Tuberculosis, Horace John
Hawk and William E. Lawson. Am. Rev. Tuberc, Bait., 1920, 4, 490-i501.
The report is that of an epidemic of smallpox occurring in a tuberculous sanatorium 6
years previously. Seven tuberculous patients contracted smallpox. The course of the small-
pox attack was not noticeably different from that in well i>eople and was apparently uninflu-
enced by the tuberculosis; likewise there was no apparent interruption in tne recovery of the
patients from tuberculosis during the course of the smallpox. Detailed records* of the seven
cases are given. — T. G. H.

$18S. Influenza as a Factor in the Activation of Latent Tuberculosis. Loms C. Boisuniere.

Am. Rev. Tuberc, Bait., 1920, 4, 534^540.

The author presents observations, opinions, and statistics showing that 15 to 20 per cent
of new cases of active tuberculosis, arismg since the onset of the 1918 epidemic of influenza,
were caused by influenza, and that the incidence of active tuberculosis has increased to the
same extent during that period and on that account. — ^T. G. H.

$184. Welche Lunge erkrankt am hUrdigsten au Tuberkuloset (Which Lung Becomes More
FrequenUy Tw>erculousT) A. E. Mater. MQnchen. med. Wchnschr.. 1920, 67, 935-936.
Examination of 2500 cases shows that the right lung is a little more frequently the site

of infection from tuberculosis than the left. — B. C.

$185. Tuberculosis Infection and Tuberctdosis, B. L. Tauafbrro. South. M. J., Bir-
mingham, 1920, 13, 574^75»
A brief paper discussing the difference between latent infection and active tuberculosis.

—J. H. B.

2186. Zur Ldsung des TuberkuHnrdtsels. (The Solution of the Tuberculin Riddle.) Hans

Much. Deutsche med. Wchnschr.. 1920, 46, 845-846.

Dilute acid splits up the tubercle bacillus into four distinct antigens: (1) water-soluble
(partigen L); (2) protem, (parti^n A): (3) fatty acid-lipoid, (partisen F); and (4) neutral
fat-aliphatic alcohol (partigen N). Study of these has indicateof the existence of the
followmg laws. Each stimulant, or mixture of reactive substances^ may be classified into
certain biological groups, or partial antigen classes, and each partial antigen has a corre-
sponding antibody. Total immunity is determinable only with the partial antigens, and
not with a mixture of them. Absence of a reaction wben whole antigen is tested does not
necessarily indicate total absence of partial antibodies^or very often a test with the single

gartial antigens will give a marked positive reaction. There exists apparently a mutual inhi-
ition of activity among the parti^ens when combined, and they become activated upon
separation. Thus, absence of reaction with Old Tuberculin is not indicative of complete
absence of antibodies. If it is separated by dialysis, one of its components will produce
a decided reaction. The reactions of sinsle partigens are different not only in kind, but in
significance. In the case of the tubercle bacillus, a reaction with partigen L is unfavorable,
while one with the others is of favorable prognosis. Reaction to pure tuberculin (such as
partigen L is considered to be) appears to indicate a toxin hypersensitiveness which is injuri-
ous; while reaction to partigens A, F, N corresponds to immune-body hypersensitiveness
which is a favorable condition.

The fundamental difference between the water-soluble and water-insoluble partial anti-
gens is revealed in the fact that treatment with water-soluble partigens (pure tuberculin)
results in a reduction of hypersensitiveness toward it, while treatment with the three water-
insoluble partigens results m an increase.

Much believes that these facts provide the solution to the numerous puzzling and con-
tradictory resudts obtained in the use of Old Tuberculin preparations in the diagnosis and
treatment of tuberculosis. — B. C.

(^ee also Numbers $084, $179, $$71)

$187. Accuracy of the Schick Reaction. Abraham Zinghbr. J. Am. M. Ass., Chicago, 1920,

76, 1333.

The accuracy of the Schick test depends upon a standard toxin dilution of proper strength,
accurate technic in injection and accurate interpretation of the reaction. Tne author found
in certaui cases the toxin offered by some commercial laboratories was not of proper potency

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and caused negative reactions or incomplete reactions when control tests made with a toxin
obtained from the research laboratory of the City of New York gave distinct reactions. —
P. G. H.

£188. Ueber Oloasitis im Sduglingsalter. (Olosaitis in Nurslings.) B. Wibnbr. Berl. klin.

Wchnschr., 1920, 57, 68»-684.

A peculiar affection of the tongue was observed in 6 infants aged 2 to 12 months, all of
whom were in poor nutritive condition. Sharply circumscribed spots with small whitish
centers appeared on the tongue and oral mucosa. There were no signs of an inflammatory
reaction m the neighboring areas or lymph glands. The disease disappeared spontaneously
after an indeterminate period varying from several days to weeks. The etiology is obscure;
it is not believed that the low nutritive state was the cause. — ^B. C.


(See also Number $$9S)

£189. Ueber die Behandlung des fiebernden Abortes. (The Treatment of Febrile Abortion.)

B. Zblnik. Wien. klin. Wchnschr., 1920, 88, 680-682.

In the treatment of septic abortion it is a question whether to wait until the febrile reac-
tion has passed or to remove at once the infected intrauterine areas. A comparison of both
methods of treatment indicate that they are equal in value as regards subsequent compli-
cations or mortality. — B. C.

£190. Eir^e InfekHonsqudle fur stillende Frauen und die Prophylaxe der Mastitis. (A Source
of Infection for Nursing Women and the Prophylaxis of Mastitis.) Leopold Fbilchbnfbld.
3erl. klin. Wchnschr., 1920, 67, 686-687.

Prophylactic treatment for ophthalmia neonatonmi with silver nitrate results in a
mild conjunctivitis in the infant lasting -sometimes for several weeks. This conjunctivitis
soon becomes purulent in character. During the nursing period the infant, by pressms its eyes
against the breast of the mother massages the eye secretions loaded with pvogenic bacteria
into the breasts and nipples. This source of infection is a veiy real one and should be guarded
against, especially by bandaging the infant's eyes during nursing. — B. C.

£191. Terpentindlinjektionen dei der Behandlung entzHndlicher Adnextumoren. (Turpentine
Oil Injections in the Treatment of Inflammatory Swellings of Uterine Adnexa.) Julius
SoNNBNFBLD. Bcrf. klin. Wchnschr., 1920, 67, 707-708.
In a total of 116 cases of inflammatory timiors (gonorrheal and non-gonorrheal) of the

female genitalia the author found that intramuscular injections of 0.6 cc. of a 20 per cent

solution of turpentine oil in olive oil resulted in a rapid subsidence of the inflammation and

early cure. — ^B. C.

£19£. Ueber die Behandlung der puerperalen Sepsis mil Fulmargin. (The Treatment of Puer-
peral Sepsis with Fulmargin.) Fritz Aron. Deutsche med. Wchnschr., Berl. & Leipz.,
1920, 46, 968-969.
CoUargol, a valuable antiseptic, has the disadvantage that it freguentl^ causes a foreign

protein reaction after intravenous injection. Fulmargin is a colloidal silver preparation

produced by the electrical dispersion of the metal, and contains no protective protein colloid.

This substance is efficacious in combating puerperal sepsis. — B. C.

(See also Numbers 1966, £18£, ££99, £308, £S1S, £S18)

£19$. Protein Sensitization in Eczema of Adults. Howard Fox and J. Edgar Fisher. J.

Am. M. Ass., Chicago, 1920. 76. 907.

Most reports on eczema published deal with eczema of infants or children. It is diffi-
cult to reach definite conclusions in regard to the value of protein skin tests in eczema of
adults. In the authors' work skin tests were made with a number of commercial proteins.
The results have varied considerably, but ultimately they 'will probably be of therapeutic
assistance in a small proportion of cases of eczema in adults. — P. G. H.

£194. Infectious Eczematoid Dermatitis. Richard L. Sutton. J. Am. M. Ass., Chicago,

1920, 76, 976.

From the cases observed the author concludes: **No one realizes better than I that our
present knowledge of anaphvlaxis, and particularly as related to the etiology of cutaneous
disorders, is far from complete. Nevertheless, I believe we may safely assert that this
phenomenon plays an important part in the prolongation, if not in the actual causation, of
many cases of infectious eczematoid dermatitis.'' — P. G. H.

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$196. An Epidemiological Study of an Endemic Focus of Leprosy, Mark F. Botd and Wabrbn

F. Fox. Pub. Health Rep., Wash., 1020, 36, 3007-3018.

The endemic area is a moaerate sized subtropical city on an island in the Gulf of Mexico,
2 or more miles distant from the mainland. In a period of 30 years, 45 cases have occurred.
The maximum number of onsets among those bom elsewhere occurred during the second
decade of residence, and among those bom locally during the second decade of life. The data
collected indicate that contact or association with cases of leprosy is concerned in the develop-
ment of the disease. — I. A. B.

$196, Treatment of Leprosy with the Dean Derivatives of ChatUmoogra Oil, Apparent Cure in
Seventy-eight Cases, J. T. McDonald. J. Am. M. Ass., Chicago, 1920, 76, 14S3.
In many nerve cases detection of the leprosy bacillus is impracticable. Since October 1,
1918, 78 patients have been paroled as no longer a menace to public health. Treatment with
chaulmoogra oil comes near to being a specific for leprosy. The oil is injected by means
of a 20 cc. all-glass Paris syringe. The site chosen is the upper and outer quadrant of the
eluteal region, the area for the puncture being painted witn tincture of lodin. Abscess
formation has been observed in only one case out of 6924 deep injections. — P. G.. H.

$197, Lupus Erythematosus and Focal Infection, M. B. Habtzell. Arch. Dermat. & Syph.,

Chicago, 1920, 2, 411 14 6.

A case is reported in which marked improvement followed the extraction of a tooth with
diseased root. The possible relation to streptococcus focal infections is discussed. — R. D. H.

$198, The Cultivation of Epidermophyton inguinale, D. L. Farley. Arch. Dermat. & Syph.,

Chicago, 1920, 2, 466-469.

Important points in technic for the successful cultivation of the organism are empha-
sized. Gentian violet blood maltose agar is the medium of choice. After careful cleansing
of the skin surface a large amount of the scrapings are obtained and transferred within a
comparatively short time to previously prepared plates. A description is given of a method
of sealing plates to prevent drying. — R. D. H.

$199. StreptodermatitiSj Especially in its relation to Wounds. D. W. Montoomebt and G. D.

Culver. Arch. Dermat. & Syph., Chicago, 2, 649-653.

The author classified streptodermatitis as an infective disease caused by an anaerobic
streptococcus. A clinical description of the condition and special considerations of treatment
are given. — ^R. D. H.

$$00, Cutaneous Reactior^s to Focal Infection, unth Clinical and Pathological Report of Two

Cases, I. L. McGlasson. Texas State J. M., 1920, 16, 166-166.

A report of two cases of skin eruptions following infection in one, of the tonsils and in the
other, the antrum. Attention to the foci of infection resulted in prompt disappearance of the
skin lesions. — J. H. B.

$$01 . Lichibehandluna bei Oeschlechtskrankheiten (kombinierte Hg- und Lichtbehandlung) nach
$0 jdhriger Erfahrung. (Heliotherapy in Sex Diseases (Combined Mercury and Hdio-

Online LibrarySociety of American BacteriologistsAbstracts of bacteriology → online text (page 79 of 103)